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The Age of Olfactor...
The Age of Olfactory Bulb Neurons in Humans
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- Bergmann, O. (author)
- Karolinska Institutet
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Liebl, J. (author)
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Bernard, S. (author)
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- Alkass, K. (author)
- Karolinska Institutet
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- Yeung, M. S. Y. (author)
- Karolinska Institutet
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Steier, P. (author)
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Kutschera, W. (author)
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Johnson, L. (author)
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Druid, H. (author)
- Karolinska Institutet
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- Spalding, K. L. (author)
- Karolinska Institutet
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- Frisen, J. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Neuron. - : Elsevier BV. - 0896-6273 .- 1097-4199. ; 74:4, s. 634-639
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Abstract
Subject headings
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- Continuous turnover of neurons in the olfactory bulb is implicated in several key aspects of olfaction. There is a dramatic decline postnatally in the number of migratory neuroblasts en route to the olfactory bulb in humans, and it has been unclear to what extent the small number of neuroblasts at later stages contributes new neurons to the olfactory bulb. We have assessed the age of olfactory bulb neurons in humans by measuring the levels of nuclear bomb test-derived C-14 in genomic DNA. We report that C-14 concentrations correspond to the atmospheric levels at the time of birth of the individuals, establishing that there is very limited, if any, postnatal neurogenesis in the human olfactory bulb. This identifies a fundamental difference in the plasticity of the human brain compared to other mammals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- neural stem-cells
- adult human brain
- chain migration
- nuclear tests
- bomb c-14
- neurogenesis
- forebrain
- differentiation
- neuroblasts
- accelerator
- vries h.
- 1958
- science
- v128
- p250
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neuron
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- By the author/editor
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Bergmann, O.
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Liebl, J.
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Bernard, S.
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Alkass, K.
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Yeung, M. S. Y.
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Steier, P.
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show more...
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Kutschera, W.
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Johnson, L.
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Landén, Mikael, ...
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Druid, H.
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Spalding, K. L.
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Frisen, J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neuron
- By the university
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University of Gothenburg
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Karolinska Institutet