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  • Raven, P. A. (author)

Growth and endocrine effects of recombinant bovine growth hormone treatment in non-transgenic and growth hormone transgenic coho salmon

  • Article/chapterEnglish2012

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  • Elsevier BV,2012

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  • LIBRIS-ID:oai:gup.ub.gu.se/160969
  • https://gup.ub.gu.se/publication/160969URI
  • https://doi.org/10.1016/j.ygcen.2012.03.002DOI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • To examine the relative growth, endocrine, and gene expression effects of growth hormone (GH) transgenesis vs. GH protein treatment, wild-type non-transgenic and GH transgenic coho salmon were treated with a sustained-release formulation of recombinant bovine GH (bGH; Posilac(TM)). Fish size, specific growth rate (SGR), and condition factor (CF) were monitored for 14 weeks, after which endocrine parameters were measured. Transgenic fish had much higher growth, SGR and CF than non-transgenic fish, and bGH injection significantly increased weight and SGR in non-transgenic but not transgenic fish. Plasma salmon GH concentrations decreased with bGH treatment in non-transgenic but not in transgenic fish where levels were similar to controls. Higher GH mRNA levels were detected in transgenic muscle and liver but no differences were observed in GH receptor (GHR) mRNA levels. In non-transgenic pituitary. GH and GHR mRNA levels per mg pituitary decreased with bGH dose to levels seen in transgenic salmon. Plasma IGF-I was elevated with bGH dose only in non-transgenic fish, while transgenic fish maintained an elevated level of IGF-I with or without bGH treatment. A similar trend was seen for liver IGF-I mRNA levels. Thus, bGH treatment increased fish growth and influenced feedback on endocrine parameters in non-transgenic but not in transgenic fish. A lack of further growth stimulation of GH transgenic fish suggests that these fish are experiencing maximal growth stimulation via GH pathways. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.

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  • Sakhrani, D. (author)
  • Beckman, B. (author)
  • Neregård, Lena,1973Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences(Swepub:gu)xnerle (author)
  • Sundström, L. Fredrik,1972 (author)
  • Björnsson, Björn Thrandur,1952Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences(Swepub:gu)xbjorb (author)
  • Devlin, R. H. (author)
  • Göteborgs universitetInstitutionen för biologi och miljövetenskap (creator_code:org_t)

Related titles

  • In:General and Comparative Endocrinology: Elsevier BV177:1, s. 143-1520016-6480

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Raven, P. A.
Sakhrani, D.
Beckman, B.
Neregård, Lena, ...
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Devlin, R. H.
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NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
and Zoology
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University of Gothenburg

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