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Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study
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Firbank, M. J. (author)
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Teodorczuk, A. (author)
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van der Flier, W. M. (author)
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Gouw, A. A. (author)
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- Wallin, Anders, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Erkinjuntti, T. (author)
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Inzitari, D. (author)
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- Wahlund, L. O. (author)
- Karolinska Institutet
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Pantoni, L. (author)
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Poggesi, A. (author)
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Pracucci, G. (author)
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Langhorne, P. (author)
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O'Brien, J. T. (author)
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(creator_code:org_t)
- 2018-01-02
- 2012
- English.
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In: British Journal of Psychiatry. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 201:1, s. 40-45
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Abstract
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- Background Brain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear. Aims To investigate the relationship between baseline and incident depression and progression of white matter changes. Method In a longitudinal multicentre pan-European study (Leukoaraiosis and Disability in the elderly, LADIS), participants aged over 64 underwent baseline magnetic resonance imaging (MRI) and clinical assessments. Repeat scans were obtained at 3 years. Depressive outcomes were assessed in terms of depressive episodes and the Geriatric Depression Scale (GDS). Progression of WMC was measured using the modified Rotterdam Progression scale. Results Progression of WMC was significantly associated with incident depression during year 3 of the study (P = 0.002) and remained significant after controlling for transition to disability, baseline WMC and baseline history of depression. There was no significant association between progression of WMC and GDS score, and no significant relationship between progression of WMC and history of depression at baseline. Conclusions Our results support the vascular depression hypothesis and implicate WMC as causal in the pathogenesis of late-life depression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- global functional decline
- hyperintensity progression
- cognitive
- decline
- elderly-patients
- blood-pressure
- follow-up
- lesions
- symptoms
- disease
- risk
- lstein mf
- 1975
- journal of psychiatric research
- v12
- p189
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Firbank, M. J.
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Teodorczuk, A.
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van der Flier, W ...
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Gouw, A. A.
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Wallin, Anders, ...
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Erkinjuntti, T.
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show more...
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Inzitari, D.
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Wahlund, L. O.
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Pantoni, L.
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Poggesi, A.
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Pracucci, G.
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Langhorne, P.
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O'Brien, J. T.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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British Journal ...
- By the university
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University of Gothenburg
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Karolinska Institutet