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The green tea polyp...
The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits amyloid-beta evoked fibril formation and neuronal cell death in vitro
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Harvey, BS (author)
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Musgrave, IF (author)
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- Ohlsson, K.S. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Fransson, Å (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Smid, SD (author)
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: FOOD CHEMISTRY. - 0308-8146. ; 129:4, s. 1729-1736
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- Alzheimer’s disease is associated with amyloid-β plaques eliciting neuronal oxidative stress. Many naturally occurring compounds have antioxidant properties, but it is unclear if this alone protects against amyloid-β exposure. This study investigated the protective effects of selected bioactive compounds against amyloid-β and pro-oxidant-evoked neurotoxicity in PC12 cells. Neither resveratrol, (−)-epigallocatechin-3-gallate, cyanidin rutinoside or grape skin extract protected PC12 cells against H2O2 or tert butyl hydroperoxide toxicity. Amyloid-β resulted in a concentration-dependent reduction in PC12 cell viability that was unaffected by resveratrol or cyanidin rutinoside pre-treatment. By contrast, (−)-epigallocatechin-3-gallate and grape skin extract significantly reduced amyloid-β-evoked neurotoxicity (by 40%). Only (−)-epigallocatechin-3-gallate was directly able to inhibit amyloid-β aggregate and fibril formation. These results suggest that (−)-epigallocatechin-3-gallate protects neuronal cells by disrupting amyloid-β fibril formation; bioactive polyphenols which disrupt fibril aggregation may confer additional neuroprotection when compared against antioxidant activity alone.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- amyloid-beta
- cyanidin rutinoside
- (-)-epigallocatechin-3-gallate
- grape skin extract
- oxidative stress
- polyphenols
- resveratrol
Publication and Content Type
- ref (subject category)
- art (subject category)
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