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Comparison of Dorso...
Comparison of Dorsocervical With Abdominal Subcutaneous Adipose Tissue in Patients With and Without Antiretroviral Therapy-Associated Lipodystrophy
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- Sevastianova, K (author)
- Minerva Institute for Medical Research, Helsinki, Finland
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- Sutinen, J (author)
- Helsinki University Central Hospital, Finland
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- Greco, D (author)
- University of Helsinki, Finland
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- Sievers, M (author)
- Medizinische Universitätsklinik, Freiburg, Germany
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- Salmenkivi, K (author)
- University of Helsinki, Finland
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- Perttila, J (author)
- Minerva Institute for Medical Research, Helsinki, Finland
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- Olkkonen, VM (author)
- Minerva Institute for Medical Research, Helsinki, Finland
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- Wågsäter, Dick (author)
- Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
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- Lidell, Martin, 1970 (author)
- Gothenburg University,Göteborgs universitet,Extern,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,External,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Sweden
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- Enerbäck, Sven, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Sweden
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- Eriksson, P (author)
- Karolinska Institutet
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- Walker, UA (author)
- University of Basel, Switzerland
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- Auvinen, P (author)
- University of Helsinki, Finland
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- Ristola, M (author)
- Helsinki University Central Hospital, Finland
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- Yki-Jarvinen, H (author)
- Helsinki University Central Hospital, Finland
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(creator_code:org_t)
- 2011-06-20
- 2011
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 60:7, s. 1894-1900
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https://liu.diva-por... (primary) (Raw object)
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Abstract
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- OBJECTIVE: Combination antiretroviral therapy (cART) is associated with lipodystrophy, i.e., loss of subcutaneous adipose tissue in the abdomen, limbs, and face and its accumulation intra-abdominally. No fat is lost dorsocervically and it can even accumulate in this region (buffalo hump). It is unknown how preserved dorsocervical fat differs from abdominal subcutaneous fat in HIV-1-infected cART-treated patients with (cART+LD+) and without (cART+LD-) lipodystrophy. RESEARCH DESIGN AND METHODS: We used histology, microarray, PCR, and magnetic resonance imaging to compare dorsocervical and abdominal subcutaneous adipose tissue in cART+LD+ (n=21) and cART+LD- (n=11). RESULTS: Albeit dorsocervical adipose tissue in cART+LD+ seems spared from lipoatrophy, its mitochondrial DNA (mtDNA; copies/cell) content was significantly lower (by 62%) than that of the corresponding tissue in cART+LD-. Expression of CD68 mRNA, a marker of macrophages, and numerous inflammatory genes in microarray were significantly lower in dorsocervical versus abdominal subcutaneous adipose tissue. Genes with the greatest difference in expression between the two depots were those involved in regulation of transcription and regionalization (homeobox genes), irrespective of lipodystrophy status. There was negligible mRNA expression of uncoupling protein 1, a gene characteristic of brown adipose tissue, in either depot. CONCLUSIONS: Because mtDNA is depleted even in the nonatrophic dorsocervical adipose tissue, it is unlikely that the cause of lipoatrophy is loss of mtDNA. Dorsocervical adipose tissue is less inflamed than lipoatrophic adipose tissue. It does not resemble brown adipose tissue. The greatest difference in gene expression between dorsocervical and abdominal subcutaneous adipose tissue is in expression of homeobox genes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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Diabetes
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- By the author/editor
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Sevastianova, K
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Sutinen, J
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Greco, D
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Sievers, M
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Salmenkivi, K
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Perttila, J
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show more...
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Olkkonen, VM
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Wågsäter, Dick
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Lidell, Martin, ...
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Enerbäck, Sven, ...
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Eriksson, P
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Walker, UA
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Auvinen, P
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Ristola, M
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Yki-Jarvinen, H
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Diabetes
- By the university
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University of Gothenburg
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Linköping University
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Karolinska Institutet