Search: onr:"swepub:oai:gup.ub.gu.se/162116" >
Boron neutron captu...
Boron neutron capture therapy for newly diagnosed glioblastoma multiforme: An assessment of clinical potential
-
Hopewell, JW (author)
-
Gorlia, T (author)
-
- Pellettieri, L (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
show more...
-
Giusti, V (author)
-
H-Stenstam, B (author)
-
Skold, K (author)
-
show less...
-
(creator_code:org_t)
- 2011
- 2011
- English.
-
In: APPLIED RADIATION AND ISOTOPES. - 0969-8043. ; 69:12, s. 1737-1740
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- Abstract: The purpose of this analysis was to assess the potential of BNCT, with L-boronophenylalanine (L-BPA), as first line radiotherapy for glioblastoma multiforme (GBM). The survival of patients with newly diagnosed GBM from a phase II BNCT study was compared with those from the two arms of a phase Ill study with conventional radiotherapy (RT) vs. RT plus concomitant and adjuvant medication with temozolomide (TMZ). A small subgroup, for which the methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) DNA-repair gene was known, was also considered. The results indicated that the use of BNCT with BPA should be explored in a stratified randomized phase II trial in which patients with the unmethylated MGMT DNA-repair gene are offered BNCT vs. RT plus TMZ. (C) 2011 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- newly diagnosed glioblastoma
- bnct
- clinical efficacy
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database