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Comprehensive Re-Se...
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Åkerström, TobiasUppsala universitet,Experimentell kirurgi
(author)
Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-07-27
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Public Library of Science (PLoS),2012
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/163898
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https://gup.ub.gu.se/publication/163898URI
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https://doi.org/10.1371/journal.pone.0041926DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125284009URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183242URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either of two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene in aldosterone producing adenomas. These mutations alter the channel selectivity filter and result in Na(+) conductance and cell depolarization, stimulating aldosterone production and cell proliferation. Because a similar mutation occurs in a Mendelian form of primary aldosteronism, these mutations appear to be sufficient for cell proliferation and aldosterone production. The prevalence and spectrum of KCNJ5 mutations in different entities of adrenocortical lesions remain to be defined.
Subject headings and genre
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Crona, JoakimUppsala universitet,Experimentell kirurgi(Swepub:uu)joacr310
(author)
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Verdugo, Alberto DelgadoUppsala universitet,Experimentell kirurgi(Swepub:uu)aldel839
(author)
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Starker, Lee F.Uppsala universitet,Experimentell kirurgi(Swepub:uu)leest428
(author)
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Cupisti, Kenko
(author)
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Willenberg, Holger S
(author)
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Knoefel, Wolfram T
(author)
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Saeger, Wolfgang
(author)
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Feller, Alfred
(author)
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Ip, Julian
(author)
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Soon, Patsy
(author)
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Anlauf, Martin
(author)
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Alesina, Pier F
(author)
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Schmid, Kurt W
(author)
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Decaussin, Myriam
(author)
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Levillain, Pierre
(author)
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Wängberg, Bo,1953Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xwanbo
(author)
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Peix, Jean-Louis
(author)
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Robinson, Bruce
(author)
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Zedenius, JanKarolinska Institutet
(author)
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Bäckdahl, MartinKarolinska Institutet
(author)
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Caramuta, StefanoKarolinska Institutet
(author)
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Iwen, K Alexander
(author)
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Botling, JohanUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)johanbot
(author)
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Stålberg, PeterUppsala universitet,Endokrinkirurgi(Swepub:uu)petestah
(author)
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Kraimps, Jean-Louis
(author)
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Dralle, Henning
(author)
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Hellman, PerUppsala universitet,Endokrinkirurgi(Swepub:uu)perhellm
(author)
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Sidhu, Stan
(author)
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Westin, GunnarUppsala universitet,Endokrinkirurgi(Swepub:uu)gunnwest
(author)
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Lehnert, Hendrik
(author)
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Walz, Martin K
(author)
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Åkerström, GöranUppsala universitet,Endokrinkirurgi(Swepub:uu)goranas
(author)
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Carling, Tobias
(author)
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Choi, Murim
(author)
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Lifton, Richard P
(author)
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Björklund, PeymanUppsala universitet,Experimentell kirurgi(Swepub:uu)pebjo957
(author)
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Uppsala universitetExperimentell kirurgi
(creator_code:org_t)
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Åkerström, Tobia ...
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Crona, Joakim
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Verdugo, Alberto ...
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Starker, Lee F.
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Cupisti, Kenko
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Willenberg, Holg ...
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Knoefel, Wolfram ...
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Saeger, Wolfgang
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Feller, Alfred
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Ip, Julian
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Soon, Patsy
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Anlauf, Martin
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Alesina, Pier F
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Schmid, Kurt W
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Decaussin, Myria ...
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Levillain, Pierr ...
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Wängberg, Bo, 19 ...
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Peix, Jean-Louis
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Robinson, Bruce
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Zedenius, Jan
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Bäckdahl, Martin
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Caramuta, Stefan ...
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Iwen, K Alexande ...
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Botling, Johan
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Stålberg, Peter
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Kraimps, Jean-Lo ...
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Dralle, Henning
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Hellman, Per
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Sidhu, Stan
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Westin, Gunnar
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Lehnert, Hendrik
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Walz, Martin K
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Åkerström, Göran
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Carling, Tobias
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Choi, Murim
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Lifton, Richard ...
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Björklund, Peyma ...
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