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Urinary excretion o...
Urinary excretion of 5-S-cysteinyldopa in relation to skin type, UVB-induced erythema, and melanocyte proliferation in human skin.
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- Stierner, Ulrika, 1952 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Rosdahl, Inger, 1943 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Augustsson, A (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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Kågedal, B (author)
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(creator_code:org_t)
- 1988
- 1988
- English.
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In: The Journal of investigative dermatology. - 0022-202X. ; 91:5, s. 506-10
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- 5-S-Cysteinyldopa (5-S-CD) is found in all pigment-producing cells and is the major precursor of phaeomelanin. However, the melanocyte specificity of the compound has been questioned. In order to elucidate the origin of 5-S-CD, we have now systematically studied the relationship between the 5-S-CD excretion in urine and the size of the melanocyte organ, UV-induced melanocyte proliferation, skin type, and the erythemal reaction. The skin type had no influence on the basal excretion of 5-S-CD. There was no significant correlation between the basal 5-S-CD excretion and the size of the melanocyte organ; that is, the number of skin melanocytes and nevi. During the irradiation, subjects with skin type II developed a more pronounced erythema (p less than 0.01) and had a significantly higher 5-S-CD excretion than those with skin type III-IV (p less than 0.01). No correlation was found between 5-S-CD excretion and UV-induced melanocyte proliferation. The lack of correlation between the basal 5-S-CD excretion and skin type or number of melanocytes suggests that the basal 5-S-CD in urine is mainly of extra-melanocytic origin. Our findings favor the view that the increase in 5-S-CD excretion during UV irradiation is due to UV damage.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adult
- Cell Division
- radiation effects
- Cysteinyldopa
- urine
- Dihydroxyphenylalanine
- analogs & derivatives
- Epidermis
- cytology
- radiation effects
- Erythema
- etiology
- pathology
- urine
- Female
- Humans
- Male
- Melanocytes
- cytology
- radiation effects
- Middle Aged
- Skin
- cytology
- radiation effects
- Tumor Markers
- Biological
- urine
- Ultraviolet Rays
- adverse effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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