Search: onr:"swepub:oai:gup.ub.gu.se/164367" >
Iodine Content and ...
-
Hansson, Marie,1979Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics
(author)
Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine: Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/164367
-
https://gup.ub.gu.se/publication/164367URI
-
https://doi.org/10.1155/2012/842357DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Patients with Graves' disease can be medically prepared before surgery in different ways, which may have various effects on iodine stores. Thyroid specimens were collected at surgery from two patients pretreated with propylthiouracil (PTU) and stable iodine, respectively. A quantitative analysis of iodine content was performed using X-ray fluorescence (XRF) in frozen tissue and a qualitative analysis of aldehyde-fixed material with Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS). Iodine concentrations were 0.9mg/mL and 0.5mg/mL in the thyroid tissue from the patients treated with PTU and stable iodine respectively. TOF-SIMS showed iodine in the follicle lumina in both. However, in the PTU case, iodine was also seen within the thyrocytes indicating accumulation of iodinated compounds from uninhibited hormone release. XRF and TOF-SIMS can be used to follow iodine distribution within the thyroid and the intricate processes following the different medical treatment alternatives in Graves' disease.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Nyström, Helena Filipsson,1966
(author)
-
Jansson, Svante,1948
(author)
-
Lausmaa, Jukka
(author)
-
Berg, Gertrud,1944Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology(Swepub:gu)xbeger
(author)
-
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för radiofysik
(creator_code:org_t)
Related titles
-
In:Case reports in endocrinology: Hindawi Limited20122090-651X2090-6501
Internet link
Find in a library
To the university's database