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Hyperfractionated V...
Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial.
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- Lannering, Birgitta, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Rutkowski, Stefan (author)
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Doz, Francois (author)
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Pizer, Barry (author)
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Gustafsson, Göran (author)
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Navajas, Aurora (author)
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Massimino, Maura (author)
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Reddingius, Roel (author)
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Benesch, Martin (author)
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Carrie, Christian (author)
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Taylor, Roger (author)
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Gandola, Lorenza (author)
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- Björk-Eriksson, Thomas, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Giralt, Jordi (author)
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Oldenburger, Foppe (author)
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Pietsch, Torsten (author)
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Figarella-Branger, Dominique (author)
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Robson, Keith (author)
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Forni, Marco (author)
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Clifford, Steven C (author)
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Warmuth-Metz, Monica (author)
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von Hoff, Katja (author)
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Faldum, Andreas (author)
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Mosseri, Véronique (author)
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Kortmann, Rolf (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 30:26, s. 3187-93
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Abstract
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- PURPOSE To compare event-free survival (EFS), overall survival (OS), pattern of relapse, and hearing loss in children with standard-risk medulloblastoma treated by postoperative hyperfractionated or conventionally fractionated radiotherapy followed by maintenance chemotherapy. PATIENTS AND METHODS In all, 340 children age 4 to 21 years from 122 European centers were postoperatively staged and randomly assigned to treatment with hyperfractionated radiotherapy (HFRT) or standard (conventional) fractionated radiotherapy (STRT) followed by a common chemotherapy regimen consisting of eight cycles of cisplatin, lomustine, and vincristine. Results After a median follow-up of 4.8 years (range, 0.1 to 8.3 years), survival rates were not significantly different between the two treatment arms: 5-year EFS was 77% ± 4% in the STRT group and 78% ± 4% in the HFRT group; corresponding 5-year OS was 87% ± 3% and 85% ± 3%, respectively. A postoperative residual tumor of more than 1.5 cm(2) was the strongest negative prognostic factor. EFS of children with all reference assessments and no large residual tumor was 82% ± 2% at 5 years. Patients with a delay of more than 7 weeks to the start of RT had a worse prognosis. Severe hearing loss was not significantly different for the two treatment arms at follow-up. CONCLUSION In this large randomized European study, which enrolled patients with standard-risk medulloblastoma from more than 100 centers, excellent survival rates were achieved in patients without a large postoperative residual tumor and without RT treatment delays. EFS and OS for HFRT was not superior to STRT, which therefore remains standard of care in this disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Lannering, Birgi ...
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Rutkowski, Stefa ...
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Doz, Francois
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Pizer, Barry
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Gustafsson, Göra ...
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Navajas, Aurora
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show more...
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Massimino, Maura
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Reddingius, Roel
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Benesch, Martin
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Carrie, Christia ...
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Taylor, Roger
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Gandola, Lorenza
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Björk-Eriksson, ...
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Giralt, Jordi
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Oldenburger, Fop ...
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Pietsch, Torsten
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Figarella-Brange ...
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Robson, Keith
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Forni, Marco
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Clifford, Steven ...
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Warmuth-Metz, Mo ...
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von Hoff, Katja
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Faldum, Andreas
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Mosseri, Véroniq ...
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Kortmann, Rolf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Journal of clini ...
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University of Gothenburg
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Karolinska Institutet