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The Sphingosine-1-P...
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2
- Article/chapterEnglish2012
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LIBRIS-ID:oai:gup.ub.gu.se/164697
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https://gup.ub.gu.se/publication/164697URI
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https://doi.org/10.1016/j.devcel.2012.08.005DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182752URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125233787URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Angiogenesis, the process by which new blood vessels arise from preexisting ones, is critical for embryonic development and is an integral part of many disease processes. Recent studies have provided detailed information on how angiogenic sprouts initiate, elongate, and branch, but less is known about how these processes cease. Here, we show that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability. Loss of S1PR1 leads to increased endothelial cell sprouting and the formation of ectopic vessel branches. Conversely, S1PR1 signaling inhibits angiogenic sprouting and enhances cell-to-cell adhesion. This correlates with inhibition of vascular endothelial growth factor-A (VEGF-A)-induced signaling and stabilization of vascular endothelial (VE)-cadherin localization at endothelial junctions. Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses.
Subject headings and genre
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Niaudet, C.Karolinska Institutet
(author)
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Hagikura, K.
(author)
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Siemsen, B. L.
(author)
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Muhl, L.Karolinska Institutet
(author)
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Hofmann, Jennifer J.Karolinska Institutet(Swepub:uu)jenho617
(author)
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Ebarasi, L.Karolinska Institutet
(author)
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Nystrom, S.Karolinska Institutet
(author)
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Rymo, Simin,1959Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xrymsi
(author)
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Chen, L. L.Karolinska Institutet
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Pang, M. F.
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Jin, YiKarolinska Institutet,Uppsala universitet,Vaskulärbiologi(Swepub:uu)jinyi632
(author)
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Raschperger, E.Karolinska Institutet
(author)
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Roswall, P.
(author)
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Schulte, D.
(author)
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Benedito, R.
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Larsson, JimmyUppsala universitet,Cancer och vaskulärbiologi(Swepub:uu)jilar813
(author)
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Hellström, MatsUppsala universitet,Cancer och vaskulärbiologi(Swepub:uu)mathe355
(author)
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Fuxe, J.Karolinska Institutet
(author)
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Uhlen, P.Karolinska Institutet
(author)
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Adams, R.
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Jakobsson, L.Karolinska Institutet
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Majumdar, ArindamUppsala universitet,Cancer och vaskulärbiologi(Swepub:uu)arima865
(author)
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Vestweber, D.
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Uv, Anne,1967Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine(Swepub:gu)xuvanz
(author)
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Betsholtz, C.Karolinska Institutet
(author)
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Karolinska InstitutetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
(creator_code:org_t)
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In:Developmental Cell: Elsevier BV23:3, s. 587-5991534-58071878-1551
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- By the author/editor
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Gaengel, K.
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Niaudet, C.
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Hagikura, K.
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Siemsen, B. L.
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Muhl, L.
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Hofmann, Jennife ...
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show more...
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Ebarasi, L.
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Nystrom, S.
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Rymo, Simin, 195 ...
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Chen, L. L.
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Pang, M. F.
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Jin, Yi
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Raschperger, E.
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Roswall, P.
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Schulte, D.
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Benedito, R.
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Larsson, Jimmy
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Hellström, Mats
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Fuxe, J.
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Uhlen, P.
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Adams, R.
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Jakobsson, L.
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Majumdar, Arinda ...
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Vestweber, D.
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Uv, Anne, 1967
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Betsholtz, C.
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- MEDICAL AND HEALTH SCIENCES
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Developmental Ce ...
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University of Gothenburg
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Uppsala University
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Karolinska Institutet