Piperidine: effects on locomotor activity and brain monoamine turnover

• The effects of piperidine HCl (PHCl) on locomotor activity, flexor reflex activity and monoamine levels, turnover, and synthesis were studied. Results indicate a sedative action and an increased turnover of noradrenaline (NA), but no effects on 5-hydroxytryptamine (5-HT) or dopamine (DA). Data obtained from flexor reflex experiments suggest that this is not secondary to alpha-adrenergic receptor blockade. One explanation might be an increased impulse activity of NA neurons, but the exact mechanism remains to be elucidated.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Keyword

Animals

Biogenic Amines/*metabolism

Brain/*metabolism

Dopamine/metabolism

Hydroxyindoleacetic Acid/metabolism

Male

Mice

Motor Activity/*drug effects

Norepinephrine/metabolism

Piperidines/*pharmacology

Reflex

Stretch/drug effects

Serotonin/metabolism

Publication and Content Type

ref (subject category)

art (subject category)