Symptomatic atherosclerosis is associated with an altered gut metagenome

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Karlsson, Fredrik,1984Chalmers tekniska högskola,Chalmers University of Technology (author)

Symptomatic atherosclerosis is associated with an altered gut metagenome

Article/chapterEnglish2012

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2012-12-04
Springer Science and Business Media LLC,2012
electronicrdacarrier

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LIBRIS-ID:oai:gup.ub.gu.se/167208
https://gup.ub.gu.se/publication/167208URI
https://doi.org/10.1038/ncomms2266DOI
https://research.chalmers.se/publication/167208URI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Recent findings have implicated the gut microbiota as a contributor of metabolic diseases through the modulation of host metabolism and inflammation. Atherosclerosis is associated with lipid accumulation and inflammation in the arterial wall, and bacteria have been suggested as a causative agent of this disease. Here we use shotgun sequencing of the gut metagenome to demonstrate that the genus Collinsella was enriched in patients with symptomatic atherosclerosis, defined as stenotic atherosclerotic plaques in the carotid artery leading to cerebrovascular events, whereas Roseburia and Eubacterium were enriched in healthy controls. Further characterization of the functional capacity of the metagenomes revealed that patient gut metagenomes were enriched in genes encoding peptidoglycan synthesis and depleted in phytoene dehydrogenase; patients also had reduced serum levels of β-carotene. Our findings suggest that the gut metagenome is associated with the inflammatory status of the host and patients with symptomatic atherosclerosis harbor characteristic changes in the gut metagenome.

Subject headings and genre

TEKNIK OCH TEKNOLOGIER Industriell bioteknik hsv//swe
ENGINEERING AND TECHNOLOGY Industrial Biotechnology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Fåk, FridaGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xfakfr (author)
Nookaew, Intawat,1977Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)intawat (author)
Tremaroli, Valentina,1978Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xtreva (author)
Fagerberg, Björn,1943Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xfagbj (author)
Petranovic Nielsen, Dina,1975Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)dinap (author)
Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xbafre (author)
Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
Chalmers tekniska högskolaWallenberglaboratoriet (creator_code:org_t)

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In:Nature Communications: Springer Science and Business Media LLC32041-1723

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