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The IncP-1 plasmid ...
The IncP-1 plasmid backbone adapts to different host bacterial species and evolves through homologous recombination.
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- Norberg, Peter, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, mikrobiologi,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Department of Cell and Molecular Biology, Microbiology,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Bergström, Maria, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, mikrobiologi,Department of Cell and Molecular Biology, Microbiology,University of Gothenburg
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- Jethava, Vinay, 1982 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Dubhashi, Devdatt, 1965 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Hermansson, Malte, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, mikrobiologi,Department of Cell and Molecular Biology, Microbiology,University of Gothenburg
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(creator_code:org_t)
- 2011-04-05
- 2011
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 2
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Abstract
Subject headings
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- Plasmids are important members of the bacterial mobile gene pool, and are among the most important contributors to horizontal gene transfer between bacteria. They typically harbour a wide spectrum of host beneficial traits, such as antibiotic resistance, inserted into their backbones. Although these inserted elements have drawn considerable interest, evolutionary information about the plasmid backbones, which encode plasmid related traits, is sparse. Here we analyse 25 complete backbone genomes from the broad-host-range IncP-1 plasmid family. Phylogenetic analysis reveals seven clades, in which two plasmids that we isolated from a marine biofilm represent a novel clade. We also found that homologous recombination is a prominent feature of the plasmid backbone evolution. Analysis of genomic signatures indicates that the plasmids have adapted to different host bacterial species. Globally circulating IncP-1 plasmids hence contain mosaic structures of segments derived from several parental plasmids that have evolved in, and adapted to, different, phylogenetically very distant host bacterial species.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Bacteria
- classification
- genetics
- DNA Transposable Elements
- Evolution
- Molecular
- Molecular Sequence Data
- Phylogeny
- Plasmids
- genetics
- Recombination
- Genetic
- Plasmids
Publication and Content Type
- ref (subject category)
- art (subject category)
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