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Metastasin S100A4 i...
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Erlandsson, Malin,1972Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
(author)
Metastasin S100A4 is increased in proportion to radiographic damage in patients with RA.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-01-17
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Oxford University Press (OUP),2012
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/169663
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https://gup.ub.gu.se/publication/169663URI
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https://doi.org/10.1093/rheumatology/ker362DOI
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https://lup.lub.lu.se/record/2336195URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: To assess the potential of metastasin S100A4 as a biological marker in patients with RA. METHODS: A total of 87 unselected patients with established RA (disease duration 2-44 years) and treated with MTX and infliximab at a single rheumatology centre were included in a cross-sectional study. Radiographs of hands and feet were taken prior to infliximab treatment and at inclusion (time interval 48±27 months) and scored for the radiographic damage. S100A4 levels were analysed in relation to radiographic damage, clinical disease activity (DAS-28), inflammation (IL-6, CRP, ESR), bone and cartilage markers [MMP-3, COMP, C-telopeptide of type I collagen (CTX-I)] and proto-oncogenes [survivin, insulin-like growth factor 1 (IGF-1), Flt3 ligand]. RESULTS: High levels of S100A4 were associated with severe radiographic damage (OR=3.40, P=0.025), non-response to infliximab (OR=4.63, P=0.003), presence of antibodies to infliximab (OR=6.24, P=0.003) and high levels of Flt3 ligand (OR=2.73, P=0.04). Regression analysis showed that high S100A4 was predictive for radiographic progression during infliximab treatment [positive predictive value (PPV) 0.68, P=0.05]. Low levels of S100A4 were associated with response to infliximab (OR=2.67, P=0.049), clinical remission (OR=4.01, P=0.0047) and negative RF (OR=9.22, P=0.0047). S100A4 correlated with survivin (r=0.71, P>0.0001). CONCLUSION: S100A4 levels are increased in proportion to radiographic damage and its further progression in RA patients. High S100A4 levels were associated with a poor clinical response to infliximab and high rate of anti-infliximab antibodies. The finding of a correlation between S100A4 and survivin and Flt3 ligand suggests that these proteins may represent a new cluster of biomarkers predicting radiographic progression and poor treatment response in RA patients.
Subject headings and genre
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Forslind, KristinaLund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-kfi
(author)
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Andersson, Sofia E M,1979Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xasofr
(author)
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Lund, AnnelieGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
(author)
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Bokarewa, Maria,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xbokma
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
Related titles
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In:Rheumatology (Oxford, England): Oxford University Press (OUP)51:5, s. 932-401462-03321462-0324
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