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Changes of the p16 ...
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Asp, Julia,1973Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
(author)
Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues.
- Article/chapterEnglish2000
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LIBRIS-ID:oai:gup.ub.gu.se/170119
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https://gup.ub.gu.se/publication/170119URI
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The role of two important tumour suppressor genes, p16 and p53, was evaluated in cartilaginous tumour tissues. Genomic DNA from 22 chondrosarcomas, 5 benign chondroid tumours, 1 sample of reactive proliferative cartilage and 2 samples of normal cartilage were analysed using polymerase chain reaction, single strand conformational polymorphism, DNA sequencing and methylation-specific polymerase chain reaction. The p16 gene was found to be partly methylated in 5 high-grade chondrosarcomas and homozygously deleted in 1 chondrosarcoma. Moreover, a polymorphism was detected in 3 malignant tumours, but not in benign tumours or normal cartilage. Analysis of the p53 gene revealed an unchanged structure in all samples. These findings show a role for p16, but not p53, in chondrosarcoma.
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Sangiorgi, L
(author)
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Inerot, Sven,1948Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics(Swepub:gu)xinesv
(author)
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Lindahl, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine(Swepub:gu)xlandy
(author)
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Molendini, L
(author)
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Benassi, M S
(author)
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Picci, P
(author)
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Göteborgs universitetInstitutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
(creator_code:org_t)
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In:International journal of cancer. Journal international du cancer85:6, s. 782-60020-7136
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Asp, Julia, 1973
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Sangiorgi, L
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Inerot, Sven, 19 ...
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Molendini, L
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Benassi, M S
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Picci, P
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