Search: onr:"swepub:oai:gup.ub.gu.se/170512" > High-throughput int...
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000 | 04000naa a2200541 4500 | |
001 | oai:gup.ub.gu.se/170512 | |
003 | SwePub | |
008 | 240528s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1705122 URI |
024 | 7 | a https://doi.org/10.1016/j.ygyno.2012.11.0372 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Garcia-Dios, Diego A4 aut |
245 | 1 0 | a High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma. |
264 | 1 | b Elsevier BV,c 2013 |
520 | a OBJECTIVE: Endometrial cancer patients may benefit from systemic adjuvant chemotherapy, alone or in combination with targeted therapies. Prognostic and predictive markers are needed, however, to identify patients amenable for these therapies. METHODS: Primary endometrial tumors were genotyped for >100 hot spot mutations in genes potentially acting as prognostic or predictive markers. Mutations were correlated with tumor characteristics in a discovery cohort, replicated in independent cohorts and finally, confirmed in the overall population (n=1063). RESULTS: PIK3CA, PTEN and KRAS mutations were most frequently detected, respectively in 172 (16.2%), 164 (15.4%) and 161 (15.1%) tumors. Binary logistic regression revealed that PIK3CA mutations were more common in high-grade tumors (OR=2.03; P=0.001 for grade 2 and OR=1.89; P=0.012 for grade 3 compared to grade 1), whereas a positive TP53 status correlated with type II tumors (OR=11.92; P<0.001) and PTEN mutations with type I tumors (OR=19.58; P=0.003). Conversely, FBXW7 mutations correlated with positive lymph nodes (OR=3.38; P=0.045). When assessing the effects of individual hot spot mutations, the H1047R mutation in PIK3CA correlated with high tumor grade and reduced relapse-free survival (HR=2.18; P=0.028). CONCLUSIONS: Mutations in PIK3CA, TP53, PTEN and FBXW7 correlate with high tumor grade, endometrial cancer type and lymph node status, whereas PIK3CA H1047R mutations serve as prognostic markers for relapse-free survival in endometrial cancer patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
653 | a Endometrial cancer | |
653 | a Clinical molecular genetics | |
653 | a Molecular biomarkers | |
653 | a Oncogenes | |
653 | a Tumor suppressor genes | |
700 | 1 | a Lambrechts, Diether4 aut |
700 | 1 | a Coenegrachts, Lieve4 aut |
700 | 1 | a Vandenput, Ingrid4 aut |
700 | 1 | a Capoen, An4 aut |
700 | 1 | a Webb, Penelope M4 aut |
700 | 1 | a Ferguson, Kaltin4 aut |
700 | 1 | a Anecs,4 aut |
700 | 1 | a Akslen, Lars A4 aut |
700 | 1 | a Claes, Bart4 aut |
700 | 1 | a Vergote, Ignace4 aut |
700 | 1 | a Moerman, Philippe4 aut |
700 | 1 | a Van Robays, Johan4 aut |
700 | 1 | a Marcickiewicz, Januszu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xmarcj |
700 | 1 | a Salvesen, Helga B4 aut |
700 | 1 | a Spurdle, Amanda B4 aut |
700 | 1 | a Amant, Frédéric4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
773 | 0 | t Gynecologic Oncologyd : Elsevier BVg 128:2, s. 327-334q 128:2<327-334x 0090-8258x 1095-6859 |
856 | 4 8 | u https://gup.ub.gu.se/publication/170512 |
856 | 4 8 | u https://doi.org/10.1016/j.ygyno.2012.11.037 |
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