Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight.

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Tyrrell, Jessica (author)

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight.

Article/chapterEnglish2012

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2012-09-05
Oxford University Press (OUP),2012

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LIBRIS-ID:oai:gup.ub.gu.se/170607
https://gup.ub.gu.se/publication/170607URI
https://doi.org/10.1093/hmg/dds372DOI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is not clear. We aimed to investigate the association between this variant and birth weight of term, singleton offspring in a well-powered meta-analysis. We stratified 26 241 European origin study participants by smoking status (women who smoked during pregnancy versus women who did not smoke during pregnancy) and, in each stratum, analysed the association between maternal rs1051730 genotype and offspring birth weight. There was evidence of interaction between genotype and smoking (P = 0.007). In women who smoked during pregnancy, each additional smoking-related T-allele was associated with a 20 g [95% confidence interval (95% CI): 4-36 g] lower birth weight (P = 0.014). However, in women who did not smoke during pregnancy, the effect size estimate was 5 g per T-allele (95% CI: -4to 14 g; P = 0.268). To conclude, smoking status during pregnancy modifies the association between maternal rs1051730 genotype and offspring birth weight. This strengthens the evidence that smoking during pregnancy is causally related to lower offspring birth weight and suggests that population interventions that effectively reduce smoking in pregnant women would result in a reduced prevalence of low birth weight.

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Huikari, Ville (author)
Christie, Jennifer T (author)
Cavadino, Alana (author)
Bakker, Rachel (author)
Brion, Marie-Jo A (author)
Geller, Frank (author)
Paternoster, Lavinia (author)
Myhre, Ronny (author)
Potter, Catherine (author)
Johnson, Paul C D (author)
Ebrahim, Shah (author)
Feenstra, Bjarke (author)
Hartikainen, Anna-Liisa (author)
Hattersley, Andrew T (author)
Hofman, Albert (author)
Kaakinen, Marika (author)
Lowe, Lynn P (author)
Magnus, PerGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology (author)
McConnachie, Alex (author)
Melbye, Mads (author)
Ng, Jane W Y (author)
Nohr, Ellen A (author)
Power, Chris (author)
Ring, Susan M (author)
Sebert, Sylvain P (author)
Sengpiel, Verena,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xsenve (author)
Taal, H Rob (author)
Watt, Graham C M (author)
Sattar, Naveed (author)
Relton, Caroline L (author)
Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo (author)
Frayling, Timothy M (author)
Sørensen, Thorkild I A (author)
Murray, Jeffrey C (author)
Lawlor, Debbie A (author)
Pennell, Craig E (author)
Jaddoe, Vincent W V (author)
Hypponen, Elina (author)
Lowe, William L (author)
Jarvelin, Marjo-Riitta (author)
Davey Smith, George (author)
Freathy, Rachel M (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)

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In:Human molecular genetics: Oxford University Press (OUP)21:24, s. 5344-53581460-20830964-6906

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By the author/editor: Tyrrell, Jessica; Huikari, Ville; Christie, Jennif ...; Cavadino, Alana; Bakker, Rachel; Brion, Marie-Jo ...; show more...; Geller, Frank; Paternoster, Lav ...; Myhre, Ronny; Potter, Catherin ...; Johnson, Paul C ...; Ebrahim, Shah; Feenstra, Bjarke; Hartikainen, Ann ...; Hattersley, Andr ...; Hofman, Albert; Kaakinen, Marika; Lowe, Lynn P; Magnus, Per; McConnachie, Ale ...; Melbye, Mads; Ng, Jane W Y; Nohr, Ellen A; Power, Chris; Ring, Susan M; Sebert, Sylvain ...; Sengpiel, Verena ...; Taal, H Rob; Watt, Graham C M; Sattar, Naveed; Relton, Caroline ...; Jacobsson, Bo, 1 ...; Frayling, Timoth ...; Sørensen, Thorki ...; Murray, Jeffrey ...; Lawlor, Debbie A; Pennell, Craig E; Jaddoe, Vincent ...; Hypponen, Elina; Lowe, William L; Jarvelin, Marjo- ...; Davey Smith, Geo ...; Freathy, Rachel ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: Human molecular ...

By the university: University of Gothenburg

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