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Circulating caroten...
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Eliassen, A Heather
(author)
Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-12-18
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Oxford University Press (OUP),2012
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/171386
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https://gup.ub.gu.se/publication/171386URI
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https://doi.org/10.1093/jnci/djs461DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-64966URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background Carotenoids, micronutrients in fruits and vegetables, may reduce breast cancer risk. Most, but not all, past studies of circulating carotenoids and breast cancer have found an inverse association with at least one carotenoid, although the specific carotenoid has varied across studies. Methods We conducted a pooled analysis of eight cohort studies comprising more than 80% of the world's published prospective data on plasma or serum carotenoids and breast cancer, including 3055 case subjects and 3956 matched control subjects. To account for laboratory differences and examine population differences across studies, we recalibrated participant carotenoid levels to a common standard by reassaying 20 plasma or serum samples from each cohort together at the same laboratory. Using conditional logistic regression, adjusting for several breast cancer risk factors, we calculated relative risks (RRs) and 95% confidence intervals (CIs) using quintiles defined among the control subjects from all studies. All P values are two-sided. Results Statistically significant inverse associations with breast cancer were observed for α-carotene (top vs bottom quintile RR = 0.87, 95% CI = 0.71 to 1.05, Ptrend = .04), β-carotene (RR = 0.83, 95% CI = 0.70 to 0.98, Ptrend = .02), lutein+zeaxanthin (RR = 0.84, 95% CI = 0.70 to 1.01, Ptrend = .05), lycopene (RR = 0.78, 95% CI = 0.62 to 0.99, Ptrend = .02), and total carotenoids (RR = 0.81, 95% CI = 0.68 to 0.96, Ptrend = .01). β-Cryptoxanthin was not statistically significantly associated with risk. Tests for heterogeneity across studies were not statistically significant. For several carotenoids, associations appeared stronger for estrogen receptor negative (ER(-)) than for ER(+) tumors (eg, β-carotene: ER(-): top vs bottom quintile RR = 0.52, 95% CI = 0.36 to 0.77, Ptrend = .001; ER(+): RR = 0.83, 95% CI = 0.66 to 1.04, Ptrend = .06; Pheterogeneity = .01). Conclusions This comprehensive prospective analysis suggests women with higher circulating levels of α-carotene, β-carotene, lutein+zeaxanthin, lycopene, and total carotenoids may be at reduced risk of breast cancer.
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Hendrickson, Sara J
(author)
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Brinton, Louise A
(author)
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Buring, Julie E
(author)
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Campos, Hannia
(author)
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Dai, Qi
(author)
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Dorgan, Joanne F
(author)
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Franke, Adrian A
(author)
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Gao, Yu-Tang
(author)
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Goodman, Marc T
(author)
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Hallmans, GoeranUmeå universitet,Enheten för biobanksforskning(Swepub:umu)goha0001
(author)
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Helzlsouer, Kathy J
(author)
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Hoffman-Bolton, Judy
(author)
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Hulten, KerstinUmeå universitet,Epidemiologi och global hälsa(Swepub:umu)kehu0001
(author)
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Sesso, Howard D
(author)
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Sowell, Anne L
(author)
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Tamimi, Rulla M
(author)
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Toniolo, Paolo
(author)
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Wilkens, Lynne R
(author)
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Winkvist, Anna,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xwinan
(author)
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Zeleniuch-Jacquotte, Anne
(author)
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Zheng, Wei
(author)
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Hankinson, Susan E
(author)
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Umeå universitetEnheten för biobanksforskning
(creator_code:org_t)
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In:Journal of the National Cancer Institute: Oxford University Press (OUP)104:24, s. 1905-161460-21050027-8874
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Buring, Julie E
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Campos, Hannia
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Dai, Qi
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Dorgan, Joanne F
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Franke, Adrian A
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Gao, Yu-Tang
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Goodman, Marc T
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Hallmans, Goeran
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Helzlsouer, Kath ...
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Hoffman-Bolton, ...
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Hulten, Kerstin
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Sesso, Howard D
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Sowell, Anne L
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Tamimi, Rulla M
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Toniolo, Paolo
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Wilkens, Lynne R
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Winkvist, Anna, ...
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Zeleniuch-Jacquo ...
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