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Sökning: onr:"swepub:oai:gup.ub.gu.se/173544" > Novel rat model rev...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003584naa a2200373 4500
001oai:gup.ub.gu.se/173544
003SwePub
008240528s2013 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1735442 URI
0247 a https://doi.org/10.1016/j.ijcard.2012.12.0922 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Shao, Yangzhen,d 1981u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xshaya
2451 0a Novel rat model reveals important roles of β-adrenoreceptors in stress-induced cardiomyopathy.
264 1b Elsevier BV,c 2013
520 a BACKGROUND: Stress-induced cardiomyopathy (SIC), also known as Takotsubo cardiomyopathy, is an acute cardiac syndrome with substantial morbidity and mortality. The unique hallmark of SIC is extensive ventricular akinesia involving apical segments with preserved function in basal segments. Adrenergic overstimulation plays an important role in initiating SIC but the pathophysiological pathways and receptors involved are unknown. METHODS: Sprague Dawley rats (~300g) were injected with a single dose of the β-adrenergic agonist isoprenaline (ISO, i.p.) and echocardiography was used to study cardiac function. The akinetic part of the left ventricle was biopsied in six SIC patients. Amount of intracellular lipid and glycogen as well as degree of permanent cardiac damage were assessed by histology. RESULTS: In rats, ISO at doses ≥50mg/kg induced severe SIC-like regional akinesia that completely resolved within seven days. Intracellular lipid content was higher in akinetic, but not in normokinetic myocardium in both SIC patients and rats. β2-receptor blockade or Gi-pathway inhibition was associated with less widespread akinesia and low lipid accumulation but significantly increased acute mortality. CONCLUSIONS: We provide a novel rat model of SIC that supports the hypothesis of circulating catecholamines as initiators of SIC. We propose that the β-adrenoreceptor pathway is important in the setting of severe catecholamine overstimulation and that perturbations of cardiac metabolism occur in SIC.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Redfors, Björnu Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xredbj
7001 a Scharin Täng, Margareta,d 1962u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xscham
7001 a Möllmann, Helge4 aut
7001 a Troidl, Christian4 aut
7001 a Szardien, Sebastian4 aut
7001 a Hamm, Christian4 aut
7001 a Nef, Holger4 aut
7001 a Borén, Jan,d 1963u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xborej
7001 a Omerovic, Elmir,d 1968u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xomeel
7102 a Göteborgs universitetb Wallenberglaboratoriet4 org
7730 t International journal of cardiologyd : Elsevier BVg 168:3, s. 1943-1950q 168:3<1943-1950x 1874-1754x 0167-5273
8564 8u https://gup.ub.gu.se/publication/173544
8564 8u https://doi.org/10.1016/j.ijcard.2012.12.092

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