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End-stage renal dis...
End-stage renal disease and low level exposure to lead, cadmium and mercury; a population-based, prospective nested case-referent study in Sweden.
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- Nilsson Sommar, Johan (författare)
- Umeå universitet,Yrkes- och miljömedicin
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- Svensson, Maria K (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine-Nephrology, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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- Björ, Bodil (författare)
- Umeå universitet,Yrkes- och miljömedicin
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- Elmståhl, Sölve (författare)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatric Medicine,Lund University Research Groups
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning,Arcum
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- Lundh, Thomas (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Schön, Staffan Mi (författare)
- Diaverum Renal Services Group, Lund, Sweden & Swedish Renal Registry, Jönköping, Sweden
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- Skerfving, Staffan (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Bergdahl, Ingvar (författare)
- Umeå universitet,Yrkes- och miljömedicin,Arcum
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(creator_code:org_t)
- BioMed Central (BMC), 2013
- 2013
- Engelska.
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Ingår i: Environmental health : a global access science source. - : BioMed Central (BMC). - 1476-069X. ; 12
- Relaterad länk:
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https://gup.ub.gu.se... (primary) (free)
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http://www.ehjournal...
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https://umu.diva-por... (primary) (Raw object)
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- ABSTRACT: Background: Cadmium (Cd), lead (Pb), and mercury (Hg) cause toxicological renal effects, but the clinical relevance at low-level exposures in general populations is unclear. The objective of this study is to assess the risk of developing end-stage renal disease in relation to Cd, Pb, and Hg exposure. Methods: A total of 118 cases who later in life developed end-stage renal disease, and 378 matched (sex, age, area, and time of blood sampling) referents were identified among participants in two population-based prospective cohorts (130,000 individuals). Cd, Pb, and Hg concentrations were determined in prospectively collected samples. Results: Erythrocyte lead was associated with an increased risk of developing end-stage renal disease (mean in cases 76 μg/L; odds ratio (OR) 1.54 for an interquartile range increase, 95% confidence interval (CI) 1.18-2.00), while erythrocyte mercury was negatively associated (2.4 μg/L; OR 0.75 for an interquartile range increase, CI 0.56-0.99). For erythrocyte cadmium, the OR of developing end-stage renal disease was 1.15 for an interquartile range increase (CI 0.99-1.34; mean Ery-Cd among cases: 1.3 μg/L). The associations for erythrocyte lead and erythrocyte mercury, but not for erythrocyte cadmium, remained after adjusting for the other two metals, smoking, BMI, diabetes, and hypertension. Gender-specific analyses showed that men carried almost all of the erythrocyte lead and erythrocyte cadmium associated risks. Conclusions: Erythrocyte lead is associated with end-stage renal disease but further studies are needed to evaluate causality. Gender-specific analyses suggest potential differences in susceptibility or in exposure biomarker reliability.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Biobank
- Cadmium
- Case-referent
- End-stage renal disease
- Lead
- Mercury
- Biobank; Cadmium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Nilsson Sommar, ...
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Svensson, Maria ...
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Björ, Bodil
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Elmståhl, Sölve
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Hallmans, Göran, ...
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Lundh, Thomas
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Schön, Staffan M ...
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Skerfving, Staff ...
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Bergdahl, Ingvar
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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Environmental he ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Lunds universitet