Search: onr:"swepub:oai:gup.ub.gu.se/175440" > Altered C-tactile p...
Fältnamn | Indikatorer | Metadata |
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000 | 05730naa a2200589 4500 | |
001 | oai:gup.ub.gu.se/175440 | |
003 | SwePub | |
008 | 240528s2013 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-126209 | |
024 | 7 | a https://gup.ub.gu.se/publication/1754402 URI |
024 | 7 | a https://doi.org/10.1016/j.pain.2012.10.0242 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1262092 URI |
040 | a (SwePub)gud (SwePub)liu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Liljencrantz, Jaquetteu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xlijaq |
245 | 1 0 | a Altered C-tactile processing in human dynamic tactile allodynia |
264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2013 |
520 | a Human unmyelinated (C) tactile afferents signal the pleasantness of gentle skin stroking on hairy (nonglabrous) skin. After neuronal injury, that same type of touch can elicit unpleasant sensations: tactile allodynia. The prevailing pathophysiological explanation is a spinal cord sensitization, triggered by nerve injury, which enables Aβ afferents to access pain pathways. However, a recent mouse knockout study demonstrates that C-tactile afferents are necessary for allodynia to develop, suggesting a role for not only Aβ but also C-tactile afferent signaling. To examine the contribution of C-tactile afferents to the allodynic condition in humans, we applied the heat/capsaicin model of tactile allodynia in 43 healthy subjects and in 2 sensory neuronopathy patients lacking Aβ afferents. Healthy subjects reported tactile-evoked pain, whereas the patients did not. Instead, patients reported their C-touch percept (faint sensation of pleasant touch) to be significantly weaker in the allodynic zone compared to untreated skin. Functional magnetic resonance imaging in 18 healthy subjects and in 1 scanned patient indicated that stroking in the allodynic and control zones evoked different responses in the primary cortical receiving area for thin fiber signaling, the posterior insular cortex. In addition, reduced activation in the medial prefrontal cortices, key areas for C-tactile hedonic processing, was identified. These findings suggest that dynamic tactile allodynia is associated with reduced C-tactile mediated hedonic touch processing. Nevertheless, because the patients did not develop allodynic pain, this seems dependent on Aβ signaling, at least under these experimental conditions. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a C-tactile afferents | |
653 | a Functional magnetic resonance imaging | |
653 | a Neuropathic pain | |
653 | a Psychophysics | |
653 | a Tactile | |
653 | a human hairy skin | |
653 | a posterior insular cortex | |
653 | a bold-contrast sensitivity | |
653 | a rat spinal-cord | |
653 | a secondary hyperalgesia | |
653 | a myelinated afferents | |
653 | a neuropathic pain | |
653 | a unmyelinated afferents | |
653 | a sensory neuronopathy | |
653 | a mechanical allodynia | |
653 | a C-tactile afferents | |
700 | 1 | a Björnsdotter, Malinu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:liu)malab53 |
700 | 1 | a Morrison, India,d 1972u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xmorin |
700 | 1 | a Bergstrand, Simonu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut |
700 | 1 | a Ceko, M.u Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada4 aut |
700 | 1 | a Seminowicz, D. A.u Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada4 aut |
700 | 1 | a Cole, J.u Department of Clinical Neurophysiology, Poole Hospital and University of Bournemouth, Bournemouth, UK4 aut |
700 | 1 | a Bushnell, M. C.u Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada4 aut |
700 | 1 | a Olausson, Håkan,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; Department of Integrative Physiology, School of Medicine, University of Western Sydney, Sydney, Australia4 aut0 (Swepub:gu)xolaha |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org |
773 | 0 | t Paind : Ovid Technologies (Wolters Kluwer Health)g 154:2, s. 227-234q 154:2<227-234x 0304-3959x 1872-6623 |
856 | 4 8 | u https://gup.ub.gu.se/publication/175440 |
856 | 4 8 | u https://doi.org/10.1016/j.pain.2012.10.024 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-126209 |
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