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Insulin-like growth...
Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG).
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Albani, D (author)
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Mazzuco, S (author)
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Batelli, S (author)
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Signorini, A (author)
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Ongaro, F (author)
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- Gustafson, Deborah, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Antuono, P (author)
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Gajo, GB (author)
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Durante, L (author)
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Caberlotto, L (author)
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Zanardo, A (author)
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Siculi, M (author)
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Gallucci, M (author)
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Forloni, GL (author)
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: The Aging Male. - 1368-5538. ; 14:4, s. 257-264
- Related links:
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https://gup.ub.gu.se...
Abstract
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- Insulin-like growth factor 1 (IGF-1) signaling modulation has been associated with increased lifespan in model organisms, while high levels of circulating interleukin-6 (IL-6) are a marker of disability and mortality. In the prospective, population-based "Treviso Longeva"--TRELONG Study from Italy (n = 668, age range 70-105.5 years at baseline, followed for seven years) we investigated the effects of survival on the IGF-1 receptor (IGF-1R) gene polymorphism rs2229765, the IL-6 gene promoter polymorphism rs1800795, and plasma concentrations of IGF-1 and IL-6, alone or in combination. We found a sex-dependent effect for the IGF-1R rs2229765 polymorphism, as male carriers of the homozygous A/A genotype survived longer, while the IL-6 rs1800795 genotype did not influence overall or sex-specific longevity. Higher IL-6 levels were more detrimental for survival among males than females, while IGF-1 had no dose-response effect. These findings sustain the hypothesis that sex-specific longevity relies on detectable differences in genetic and biochemical parameters between males and females.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Albani, D
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Mazzuco, S
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Batelli, S
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Signorini, A
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Ongaro, F
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Gustafson, Debor ...
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show more...
-
Antuono, P
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Gajo, GB
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Durante, L
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Caberlotto, L
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Zanardo, A
-
Siculi, M
-
Gallucci, M
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Forloni, GL
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
- Articles in the publication
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The Aging Male
- By the university
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University of Gothenburg