onr:"swepub:oai:gup.ub.gu.se/176539"
Search: onr:"swepub:oai:gup.ub.gu.se/176539" > The effect of a som...
- 1 of 1
- Previous record
- Next record
- To hitlist
The effect of a somatostatin analogue on the release of hormones from human midgut carcinoid tumour cells.
-
- Wängberg, Bo, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
-
- Nilsson, Ola, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
- Theodorsson, E (author)
- show more...
- Dahlström, A (author)
- show less...
- (creator_code:org_t)
- 1991
- 1991
- English.
- In: British journal of cancer. - 0007-0920. ; 64:1, s. 23-8
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The use of a somatostatin analogue (SMS 201-995) has greatly facilitated the treatment of patients with the midgut carcinoid syndrome. Clinical studies have shown that SMS reduces the peripheral levels of tumour-produced serotonin (5-HT) and tachykinins, e.g. neuropeptide K (NPK), basally and after pentagastrin provocation. Some studies have indicated an inhibitory effect of SMS on tumour cell growth as well. In the present study we have investigated the effects of SMS on four different human midgut carcinoid tumours maintained in long term culture. Media levels of 5-HT and NPK-LI in tumour cell cultures decreased rapidly during incubation with SMS (10(-8)-10(-10) M) in all four tumours studied without evidence for tachyphylaxis (up to 6 weeks observation period). SMS treatment (10(-8) M) during 4 days reduced the media concentrations of 5-HT by 56%, while the intracellular contents of 5-HT were decreased by 27% indicating dual inhibitory effects on synthesis and secretion of 5-HT from tumour cells. The DNA contents of cultures were not affected by SMS (10(-8) M or 10(-10) M) treatment for 4 or 14 days. When tumour cell cultures were challenged with isoprenaline (IP) (10(-6) M) no reduction of the IP induced release of 5-HT could be detected after pretreatment of tumour cell cultures with SMS (10(-8) M) for 1 h, 4 h or 4 days. These studies provide evidence for a direct action of the somatostatin analogue on midgut carcinoid tumour cells, reducing both synthesis and secretion of hormones from tumour cells. This effect appears not to be related to inhibition of tumour cell growth. The inhibition of 5-HT secretion from tumour cells by SMS seems to operate via a second messenger system different from the one mediating the beta-adrenoceptor stimulated release of 5-HT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Aged
- Carcinoid Tumor
- metabolism
- pathology
- secretion
- Cells
- Cultured
- Female
- Humans
- Hydroxyindoleacetic Acid
- urine
- Kinetics
- Male
- Middle Aged
- Neoplasm Metastasis
- Neuropeptides
- secretion
- Octreotide
- pharmacology
- Serotonin
- blood
- secretion
- Tachykinins
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- British journal of cancer (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Wängberg, Bo, 19 ...
- Nilsson, Ola, 19 ...
- Theodorsson, E
- Dahlström, A
- Ahlman, Håkan, 1 ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Surgery
- Articles in the publication
- British journal ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
