Management of disseminated midgut carcinoid tumours.

• Forty-one patients with disseminated midgut carcinoid tumours were treated over a 6-year period according to a strict programme including primary surgical treatment. In 10 patients, a total remission of the disease was obtained. Patients with bilobar hepatic disease had ischaemic treatment of their liver metastases by hepatic arterial embolisation after primary surgical and medical treatment (low dose octreotide). Thus, by combining surgical, radiological and medical treatment modalities, we wanted to offer these patients optimal palliation. This treatment programme resulted in good symptomatic relief in all patients accompanied by a marked reduction in 5-hydroxyindoleacetic acid (5-HIAA) levels. At recurrence of symptoms in combination with rising 5-HIAA levels, embolisation was repeated. Ten of the treated patients have deceased during the observation period, but only 5 from their carcinoid disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Keyword

Adult

Aged

Carcinoid Tumor

drug therapy

secondary

surgery

therapy

Combined Modality Therapy

Embolization

Therapeutic

Female

Hepatectomy

Humans

Hydroxyindoleacetic Acid

analysis

Intestinal Neoplasms

drug therapy

surgery

therapy

Liver Neoplasms

secondary

therapy

Lymphatic Metastasis

Male

Malignant Carcinoid Syndrome

drug therapy

surgery

therapy

Middle Aged

Octreotide

administration & dosage

therapeutic use

Palliative Care

Skin Neoplasms

secondary

therapy

Publication and Content Type

ref (subject category)

art (subject category)