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High modal number a...
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Paulsson, KajsaLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Aneuploidi i cancer,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Aneuploidy in cancer,Lund University Research Groups
(author)
High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols.
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-05-03
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Ferrata Storti Foundation (Haematologica),2013
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/178048
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https://gup.ub.gu.se/publication/178048URI
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https://doi.org/10.3324/haematol.2013.085852DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82274URI
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https://lup.lub.lu.se/record/4272133URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127945020URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215976URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Between 1992 and 2008, 713 high hyperdiploid acute lymphoblastic leukemias in children aged 1-15 years were diagnosed and treated according to the Nordic Society for Pediatric Hematology and Oncology acute lymphoblastic leukemia 1992/2000 protocols. Twenty (2.8%) harbored t(1;19), t(9;22), der(11q23), or t(12;21). The median age was lower in the patients with 'classic' high hyperdiploidy than in those with translocation-positive high hyperdiploidy (P<0.001). Cases with triple trisomies (+4, +10, +17), comprising 50%, had higher modal numbers than the triple trisomy-negative cases (P<0.0001). The probabilities of event-free survival and overall survival were lower for those with white blood cell counts ≥50 x 109/L (P=0.017/P=0.009), ≥5% bone marrow blasts at day 29 (P=0.001/0.002), and for high risk patients (P<0.001/P=0.003), whereas event-free, but not overall, survival, was higher for cases with gains of chromosomes 4 (P<0.0001), 6 (P<0.003), 17 (P=0.010), 18 (P=0.049), and 22 (P=0.040), triple trisomies (P=0.002), and modal numbers >53/55 (P=0.020/0.024). In multivariate analyses, modal number and triple trisomies were significantly associated with superior event-free survival in separate analyses with age and white blood cell counts. When including both modal numbers and triple trisomies, only low white blood cell counts were significantly associated with superior event-free survival (P=0.009). We conclude that high modal chromosome numbers and triple trisomies are highly correlated prognostic factors and that these two parameters identify the same patient subgroup characterized by a particularly favorable outcome.
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Forestier, ErikUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)erfo0007
(author)
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Andersen, Mette Klarskov
(author)
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Autio, Kirsi
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Barbany, GiselaKarolinska Institutet
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Borgström, Georg
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Cavelier, LuciaUppsala universitet,Medicinsk genetik(Swepub:uu)lucicava
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Golovleva, IrinaUmeå universitet,Medicinsk och klinisk genetik(Swepub:umu)irgo0001
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Heim, Sverre
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Heinonen, Kristiina
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Hovland, Randi
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Johannsson, Johann H
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Kjeldsen, Eigil
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Nordgren, AnnKarolinska Institutet
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Palmqvist, Lars,1965Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine(Swepub:gu)xpalla
(author)
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Johansson, BertilLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-bjo
(author)
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Avdelningen för klinisk genetikInstitutionen för laboratoriemedicin
(creator_code:org_t)
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In:Haematologica: Ferrata Storti Foundation (Haematologica)98:9, s. 1424-14321592-87210390-6078
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Paulsson, Kajsa
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Forestier, Erik
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Andersen, Mette ...
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Autio, Kirsi
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Barbany, Gisela
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Borgström, Georg
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Cavelier, Lucia
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Golovleva, Irina
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Heim, Sverre
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Heinonen, Kristi ...
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Hovland, Randi
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Johannsson, Joha ...
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Kjeldsen, Eigil
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Nordgren, Ann
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Palmqvist, Lars, ...
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Johansson, Berti ...
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- MEDICAL AND HEALTH SCIENCES
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Haematologica
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University of Gothenburg
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Umeå University
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Lund University
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Karolinska Institutet
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Uppsala University