Adjuvant treatment with ursodeoxycholic acid prevents acute rejection in rats receiving heart allografts.

Olausson, Michael,1956Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery (author)

Adjuvant treatment with ursodeoxycholic acid (UDCA) for liver-transplant recipients has been reported to reduce the frequency of acute rejection episodes. To explore this effect further, UDCA was given to rats in an experimental heart transplantation model, with or without concomitant immunosuppressive treatment with antihymocyte globulin (ATG). UDCA was administered orally 7 days before and 14 days after transplantation. Rats treated with UDCA alone or in combination with ATG were compared with untreated controls and ATG-treated recipients. Adjuvant treatment with UDCA was found to induce prolonged graft survival and increase the amount of transplant tolerance in rats. Serum levels of bilirubin and aminotransferases were not altered irrespective of the UDCA dose given. The results indicate that UDCA has an immunomodulatory capacity that might not be restricted to the liver, but also might apply to other transplanted organs as well.

Mjörnstedt, Lars,1956 (author)
Wramner, Lars,1955Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery (author)
Persson, Hans,1948Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna,Institute of Surgical Sciences (author)
Karlberg, IGothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery (author)
Friman, Styrbjörn,1948Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery(Swepub:gu)xfrist (author)
Göteborgs universitetInstitutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi (creator_code:org_t)

In:Transplant international : official journal of the European Society for Organ Transplantation5 Suppl 10934-0874

By the author/editor: Olausson, Michae ...; Mjörnstedt, Lars ...; Wramner, Lars, 1 ...; Persson, Hans, 1 ...; Karlberg, I; Friman, Styrbjör ...

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