Search: onr:"swepub:oai:gup.ub.gu.se/179556" >
Identification of a...
-
Ketelhuth, D. F.Karolinska Institutet
(author)
Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses
- Article/chapterEnglish2011
Publisher, publication year, extent ...
-
Stockholm :Karolinska Institutet, Dept of Medicine, Solna,2011
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/179556
-
ISSN:1524-4539
-
10616/41400hdl
-
https://gup.ub.gu.se/publication/179556URI
-
https://doi.org/10.1161/CIRCULATIONAHA.111.051599DOI
-
https://lup.lub.lu.se/record/2307030URI
-
http://hdl.handle.net/10616/41400URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:123802376URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-5071URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BACKGROUND: Subendothelial deposited low-density lipoprotein particles are a known inflammatory factor in atherosclerosis. However, the causal components derived from low-density lipoprotein are still poorly defined. Apolipoprotein B100 (ApoB100) is the unexchangeable protein component of low-density lipoprotein, and the progression of atherosclerosis is associated with immune responses to ApoB100-derived peptides. In this study, we analyzed the proinflammatory activity of ApoB100 peptides in atherosclerosis. METHODS AND RESULTS: By screening a peptide library of ApoB100, we identified a distinct native peptide referred to as ApoB100 danger-associated signal 1 (ApoBDS-1), which shows sequence-specific bioactivity in stimulation of interleukin-8, CCL2, and interleukin-6. ApoBDS-1 activates mitogen-activated protein kinase and calcium signaling, thereby effecting the expression of interleukin-8 in innate immune cells. Ex vivo stimulation of carotid plaques with ApoBDS-1 enhances interleukin-8 and prostaglandin E release. Furthermore, we demonstrated that ApoBDS-1-positive peptide fragments are present in atherosclerotic lesions using immunoassays and that low-molecular-weight fractions isolated from plaque show ApoBDS-1 activity inducing interleukin-8 production. CONCLUSIONS: Our data show that ApoBDS-1 is a previously unrecognized peptide with robust proinflammatory activity, contributing to the disease-promoting effects of low-density lipoprotein in the pathogenesis of atherosclerosis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Rios, F. J.
(author)
-
Wang, Y.Karolinska Institutet
(author)
-
Liu, H.
(author)
-
Johansson, Maria E,1977Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xjmarw
(author)
-
Nordin Fredrikson, GunillaMalmö högskola,Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Fakulteten för hälsa och samhälle (HS)(Swepub:mau)hsguno
(author)
-
Hedin, U.Karolinska Institutet
(author)
-
Gidlund, M.
(author)
-
Nilsson, JanLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-jni
(author)
-
Hansson, G. K.Karolinska Institutet
(author)
-
Yan, Z. Q.Karolinska Institutet
(author)
-
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi
(creator_code:org_t)
-
Karolinska Institutet
-
Karolinska Institutet
Related titles
-
In:CirculationStockholm : Karolinska Institutet, Dept of Medicine, Solna124:221524-45390009-7322
Internet link
Find in a library
To the university's database
- By the author/editor
-
Ketelhuth, D. F.
-
Rios, F. J.
-
Wang, Y.
-
Liu, H.
-
Johansson, Maria ...
-
Nordin Fredrikso ...
-
show more...
-
Hedin, U.
-
Gidlund, M.
-
Nilsson, Jan
-
Hansson, G. K.
-
Yan, Z. Q.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Circulation
- By the university
-
University of Gothenburg
-
Lund University
-
Karolinska Institutet
-
Malmö University