Search: onr:"swepub:oai:gup.ub.gu.se/180096" >
Cell therapy for ne...
Cell therapy for neonatal hypoxia-ischemia and cerebral palsy.
-
Bennet, Laura (author)
-
Tan, Sidhartha (author)
-
Van den Heuij, Lotte (author)
-
show more...
-
Derrick, Matthew (author)
-
Groenendaal, Floris (author)
-
van Bel, Frank (author)
-
Juul, Sandra (author)
-
Back, Stephen A (author)
-
Northington, Frances (author)
-
Robertson, Nicola J (author)
-
- Mallard, Carina, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
-
Gunn, Alistair Jan (author)
-
show less...
-
(creator_code:org_t)
- 2012-04-20
- 2012
- English.
-
In: Annals of neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 71:5, s. 589-600
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Perinatal hypoxic-ischemic brain injury remains a major cause of cerebral palsy. Although therapeutic hypothermia is now established to improve recovery from hypoxia-ischemia (HI) at term, many infants continue to survive with disability, and hypothermia has not yet been tested in preterm infants. There is increasing evidence from in vitro and in vivo preclinical studies that stem/progenitor cells may have multiple beneficial effects on outcome after hypoxic-ischemic injury. Stem/progenitor cells have shown great promise in animal studies in decreasing neurological impairment; however, the mechanisms of action of stem cells, and the optimal type, dose, and method of administration remain surprisingly unclear, and some studies have found no benefit. Although cell-based interventions after completion of the majority of secondary cell death appear to have potential to improve functional outcome for neonates after HI, further rigorous testing in translational animal models is required before randomized controlled trials should be considered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Animals
- Animals
- Newborn
- Cerebral Palsy
- therapy
- Humans
- Hypoxia-Ischemia
- Brain
- therapy
- Infant
- Newborn
- Stem Cell Transplantation
- methods
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bennet, Laura
-
Tan, Sidhartha
-
Van den Heuij, L ...
-
Derrick, Matthew
-
Groenendaal, Flo ...
-
van Bel, Frank
-
show more...
-
Juul, Sandra
-
Back, Stephen A
-
Northington, Fra ...
-
Robertson, Nicol ...
-
Mallard, Carina, ...
-
Gunn, Alistair J ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Annals of neurol ...
- By the university
-
University of Gothenburg