Search: onr:"swepub:oai:gup.ub.gu.se/180628" >
Reference measureme...
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Mattsson, Niklas,1979Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
(author)
Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/180628
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https://gup.ub.gu.se/publication/180628URI
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https://doi.org/10.2217/bmm.12.39DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are increasingly used in clinical settings, research and drug trials. However, their broad-scale use on different technology platforms is hampered by the lack of standardization at the level of sample handling, determination of concentrations of analytes and the absence of well-defined performance criteria for in vitro diagnostic or companion diagnostic assays, which influences the apparent concentration of the analytes measured and the subsequent interpretation of the data. There is a need for harmonization of CSF AD biomarker assays that can reliably, across centers, quantitate CSF biomarkers with high analytical precision, selectivity and stability over long time periods. In this position paper, we discuss reference procedures for the measurement of CSF AD biomarkers, especially amyloid β42 and tau. We describe possible technical approaches, focusing on a selected reaction monitoring mass spectrometry assay as a candidate reference method for quantification of CSF amyloid β42.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Zegers, Ingrid
(author)
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Andreasson, Ulf,1968Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xaulfz
(author)
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Bjerke, Maria,1977Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xsmare
(author)
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Blankenstein, Marinus A
(author)
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Bowser, Robert
(author)
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Carrillo, Maria C
(author)
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Gobom, JohanGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xgobjo
(author)
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Heath, Theresa
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Jenkins, Rand
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Jeromin, Andreas
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Kaplow, June
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Kidd, Daniel
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Laterza, Omar F
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Lockhart, Andrew
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Lunn, Michael P
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Martone, Robert L
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Mills, Kevin
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Pannee, Josef,1979Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xpajos
(author)
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Ratcliffe, Marianne
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Shaw, Leslie M
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Simon, Adam J
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Soares, Holly
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Teunissen, Charlotte E
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Verbeek, Marcel M
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Umek, Robert M
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Vanderstichele, Hugo
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Portelius, Erik,1977Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xporer
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Biomarkers in medicine: Future Medicine Ltd6:4, s. 409-171752-03711752-0363
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Mattsson, Niklas ...
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Zegers, Ingrid
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Andreasson, Ulf, ...
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Bjerke, Maria, 1 ...
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Blankenstein, Ma ...
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Bowser, Robert
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Carrillo, Maria ...
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Gobom, Johan
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Heath, Theresa
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Jenkins, Rand
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Jeromin, Andreas
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Kaplow, June
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Kidd, Daniel
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Laterza, Omar F
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Lockhart, Andrew
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Lunn, Michael P
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Martone, Robert ...
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Mills, Kevin
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Pannee, Josef, 1 ...
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Ratcliffe, Maria ...
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Shaw, Leslie M
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Simon, Adam J
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Soares, Holly
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Teunissen, Charl ...
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Verbeek, Marcel ...
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Umek, Robert M
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Vanderstichele, ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Portelius, Erik, ...
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