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Lower CSF amyloid b...
Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder.
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Pomara, Nunzio (author)
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Bruno, Davide (author)
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Sarreal, Antero S (author)
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Hernando, Raymundo T (author)
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Nierenberg, Jay (author)
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Petkova, Eva (author)
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Sidtis, John J (author)
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Wisniewski, Thomas M (author)
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Mehta, Pankaj D (author)
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Pratico, Domenico (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- American Psychiatric Association Publishing, 2012
- 2012
- English.
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In: The American journal of psychiatry. - : American Psychiatric Association Publishing. - 1535-7228 .- 0002-953X. ; 169:5, s. 523-30
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Abstract
Subject headings
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- Major depressive disorder is common in the elderly, and symptoms are often not responsive to conventional antidepressant treatment, especially in the long term. Soluble oligomeric and aggregated forms of amyloid beta peptides, especially amyloid beta 42, impair neuronal and synaptic function. Amyloid beta 42 is the main component of plaques and is implicated in Alzheimer's disease. Amyloid beta peptides also induce a depressive state in rodents and disrupt major neurotransmitter systems linked to depression. The authors assessed whether major depression was associated with CSF levels of amyloid beta, tau protein, and F2-isoprostanes in elderly individuals with major depressive disorder and age-matched nondepressed comparison subjects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Aged
- Amyloid beta-Peptides
- cerebrospinal fluid
- Case-Control Studies
- Depressive Disorder
- Major
- cerebrospinal fluid
- F2-Isoprostanes
- cerebrospinal fluid
- Female
- Humans
- Male
- Neuropsychological Tests
- Peptide Fragments
- cerebrospinal fluid
- Psychiatric Status Rating Scales
- tau Proteins
- cerebrospinal fluid
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pomara, Nunzio
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Bruno, Davide
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Sarreal, Antero ...
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Hernando, Raymun ...
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Nierenberg, Jay
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Petkova, Eva
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show more...
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Sidtis, John J
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Wisniewski, Thom ...
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Mehta, Pankaj D
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Pratico, Domenic ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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The American jou ...
- By the university
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University of Gothenburg