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Effect of immunothe...
Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease.
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Rinne, Juha O (author)
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Salloway, Stephen (author)
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Wei, Jenny (author)
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Black, Ronald (author)
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Grundman, Michael (author)
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Liu, Enchi (author)
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(creator_code:org_t)
- American Medical Association (AMA), 2012
- 2012
- English.
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In: Archives of neurology. - : American Medical Association (AMA). - 1538-3687 .- 0003-9942. ; 69:8, s. 1002-10
- Related links:
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https://jamanetwork....
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https://doi.org/10.1...
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Abstract
Subject headings
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- Given the slow and variable clinical course of Alzheimer disease, very large and extended clinical trials are needed to identify a beneficial clinical effect of disease-modifying treatments. Therefore, biomarkers are essential to prove that an anti-β-amyloid (Aβ) drug candidate affects both Aβ metabolism and plaque load as well as downstream pathogenic mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Aged
- Alzheimer Disease
- cerebrospinal fluid
- drug therapy
- epidemiology
- Amyloid beta-Peptides
- cerebrospinal fluid
- Antibodies
- Monoclonal
- Humanized
- therapeutic use
- Biological Markers
- cerebrospinal fluid
- Cohort Studies
- Double-Blind Method
- England
- epidemiology
- Female
- Finland
- epidemiology
- Humans
- Immunotherapy
- methods
- Male
- Middle Aged
- Peptide Fragments
- cerebrospinal fluid
- Treatment Outcome
- United States
- epidemiology
- tau Proteins
- cerebrospinal fluid
Publication and Content Type
- ref (subject category)
- art (subject category)
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