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Self-calibrated con...
Self-calibrated concentration measurements of polydisperse nanoparticles
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- Röding, Magnus, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Deschout, H. (author)
- Universiteit Gent,Ghent university
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- Braeckmans, K. (author)
- Universiteit Gent,Ghent university
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- Särkkä, Aila, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Rudemo, Mats, 1937 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2013-07-25
- 2013
- English.
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In: Journal of Microscopy. - : Wiley. - 0022-2720 .- 1365-2818. ; 252:1, s. 79-88
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Abstract
Subject headings
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- Summary Quantitative characterization of nanoparticles, e.g. accurate estimation of concentration distributions, is critical to many pharmaceutical and biological applications. We present a method that enables for the first time highly accurate size and absolute concentration measurements of polydisperse nanoparticles in solution, based on fluorescence single particle tracking, that are self-calibrated in the sense that the detection region volume is estimated based on the tracking data. The method is evaluated using simulations and experimental data of polystyrene nanospheres in water/sucrose solution. In addition, the method is used to quantify aggregation and clearance of different types of liposomes after intravenous injection in rats, where additional and more accurate information can be obtained that was previously unavailable, which can help elucidate their usefulness as drug carriers.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Keyword
- nanoparticles
- size distribution
- liposomal drug carriers
- polydispersity
- fluorescence single particle tracking
- Concentration
- single-particle tracking
- biological-fluids
- quantum dots
- fluorescence
- cells
- fluorescence
Publication and Content Type
- ref (subject category)
- art (subject category)
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