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Microcystin (-LR) i...
Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo
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Wang, X. T. (author)
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Chen, Y. (author)
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Zuo, X. T. (author)
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Ding, N. Q. (author)
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Zeng, H. J. (author)
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Zou, X. (author)
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- Han, Xiaodong (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Food and Chemical Toxicology. - : Elsevier BV. - 0278-6915. ; 60, s. 309-317
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Microcystin-LR (MC-LR) can induce apoptosis of a wide range of tissue cells including testicular cells. The purpose of the study was to find out whether the expression and phosphorylation of p53, Bcl-2 protein family proteins, Cyt c, and caspases were involved in the induction of testicular cell apoptosis by MC-LR in mice. Results showed that following exposure to MC-LR, expression of Bax, caspase 3 and caspase 8 was up-regulated. Significant increases in the phosphorylation of both p53 and Bcl-2 were identified after the administration of MC-LR. The administration of MC-LR also resulted in significant increases of c-myc, c-jun, and c-fos. In conclusion, p53, Bcl-2, Bax, Caspase 3 and Caspase 8 are involved in the regulation of MC-LR-induced apoptosis of testicular cells. The overexpression of c-myc, c-jun and c-fos suggests that MC-LR may have carcinogenic potential for testes. (C) 2013 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Microcystin-LR
- Apoptosis
- Testicular cells
- Mouse
- PROTEIN PHOSPHATASES
- DNA-DAMAGE
- LAKE TAIHU
- P53
- CYANOBACTERIA
- EXPRESSION
- TOXINS
- VITRO
- BAX
- HEPATOTOXICITY
Publication and Content Type
- ref (subject category)
- art (subject category)
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