Search: onr:"swepub:oai:gup.ub.gu.se/186588" >
Porphyromonas gingi...
Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)
-
Maresz, K. J. (author)
-
- Hellvard, Annelie (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
Sroka, A. (author)
-
show more...
-
Adamowicz, K. (author)
-
Bielecka, E. (author)
-
Koziel, J. (author)
-
Gawron, K. (author)
-
Mizgalska, D. (author)
-
Marcinska, K. A. (author)
-
Benedyk, M. (author)
-
Pyrc, K. (author)
-
Quirke, A. M. (author)
-
Jonsson, R. (author)
-
Alzabin, S. (author)
-
Venables, P. J. (author)
-
Nguyen, K. A. (author)
-
- Mydel, Piotr, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
Potempa, J. (author)
-
show less...
-
(creator_code:org_t)
- 2013-09-12
- 2013
- English.
-
In: Plos Pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 9:9
- Related links:
-
https://journals.plo...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each other both clinically and epidemiologically. Recent findings suggest a causative link between periodontal infection and rheumatoid arthritis via bacteria-dependent induction of a pathogenic autoimmune response to citrullinated epitopes. Here we showed that infection with viable periodontal pathogen Porphyromonas gingivalis strain W83 exacerbated collagen-induced arthritis (CIA) in a mouse model, as manifested by earlier onset, accelerated progression and enhanced severity of the disease, including significantly increased bone and cartilage destruction. The ability of P. gingivalis to augment CIA was dependent on the expression of a unique P. gingivalis peptidylarginine deiminase (PPAD), which converts arginine residues in proteins to citrulline. Infection with wild type P. gingivalis was responsible for significantly increased levels of autoantibodies to collagen type II and citrullinated epitopes as a PPAD-null mutant did not elicit similar host response. High level of citrullinated proteins was also detected at the site of infection with wild-type P. gingivalis. Together, these results suggest bacterial PAD as the mechanistic link between P. gingivalis periodontal infection and rheumatoid arthritis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- ACTIVE RHEUMATOID-ARTHRITIS
- CITRULLINATED PROTEINS
- PERIODONTAL-DISEASE
- PREVOTELLA-INTERMEDIA
- ALPHA-ENOLASE
- POSTTRANSLATIONAL MODIFICATIONS
- SIGNALING PATHWAYS
- AUTOIMMUNITY
- AUTOANTIBODIES
- SEVERITY
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Maresz, K. J.
-
Hellvard, Anneli ...
-
Sroka, A.
-
Adamowicz, K.
-
Bielecka, E.
-
Koziel, J.
-
show more...
-
Gawron, K.
-
Mizgalska, D.
-
Marcinska, K. A.
-
Benedyk, M.
-
Pyrc, K.
-
Quirke, A. M.
-
Jonsson, R.
-
Alzabin, S.
-
Venables, P. J.
-
Nguyen, K. A.
-
Mydel, Piotr, 19 ...
-
Potempa, J.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Plos Pathogens
- By the university
-
University of Gothenburg