Biodistribution and dosimetry of free (211)at, (125)i(-) and (131)i(-) in rats.

• Abstract (131)I is widely used for therapy in the clinic and (125)I and (131)I, and increasingly (211)At, are often used in experimental studies. It is important to know the biodistribution and dosimetry for these radionuclides to determine potential risk organs when using radiopharmaceuticals containing these radionuclides. The purpose of this study was to investigate the biodistribution of (125)I(-), (131)I(-), and free (211)At in rats and to determine absorbed doses to various organs and tissues. Male Sprague Dawley rats were injected simultaneously with 0.1-0.3MBq (125)I(-) and 0.1-0.3MBq (131)I(-), or 0.05-0.2MBq (211)At and sacrificed 1 hour to 7 days after injection. The activities and activity concentrations in organs and tissues were determined and mean absorbed doses were calculated. The biodistribution of (125)I(-) was similar to that of (131)I(-) but the biodistribution of free (211)At was different compared to (125)I(-) and (131)I(-). The activity concentration of radioiodine was higher compared with (211)At in the thyroid and lower in all extrathyroidal tissues. The mean absorbed dose per unit injected activity was highest to the thyroid. (131)I gave the highest absorbed dose to the thyroid, and (211)At gave the highest absorbed dose to all other tissues studied.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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