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Regulation of andro...
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Larsson, D. G. Joakim,1969Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi,Institute of Physiology and Pharmacology
(author)
Regulation of androgen receptors in Atlantic croaker brains by testosterone and estradiol.
- Article/chapterEnglish2002
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/187387
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https://gup.ub.gu.se/publication/187387URI
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https://doi.org/10.1016/S0016-6480(02)00503-8DOI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A nuclear androgen receptor (AR1), distinctly different from the mammalian AR, has previously been identified in the brain of the Atlantic croaker, Micropogonias undulatus. Interestingly, brain AR1 levels were higher in gonadally recrudesced than in regressed fish. Therefore, the possible involvement of gonadal steroids in the regulation of brain AR1 levels was investigated in the present study. Saturation analysis of [3H]testosterone binding showed that brain AR1 levels were significantly reduced (2-3-fold) in either the nuclear or cytosolic fractions of both males and females three weeks after gonadectomy. Implantation of gonadectomized females with testosterone or estradiol-17beta one week prior to sampling resulted in physiological plasma steroid concentrations and restored brain AR1 levels to 60-105% of those in intact or sham-operated fish. These results suggest that gonadal factors, including both androgens and estrogens, are involved in the physiological regulation of brain androgen receptors in a teleost species during the reproductive cycle.
Subject headings and genre
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NATURVETENSKAP Biologi hsv//swe
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NATURAL SCIENCES Biological Sciences hsv//eng
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Animals
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Brain
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physiology
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Estradiol
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analogs & derivatives
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chemistry
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metabolism
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Female
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Hormone Replacement Therapy
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Male
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Orchiectomy
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Ovariectomy
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Perciformes
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physiology
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Receptors
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Androgen
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metabolism
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Receptors
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Cytoplasmic and Nuclear
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metabolism
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Seasons
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Sex Characteristics
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Testosterone
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analogs & derivatives
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chemistry
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metabolism
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Up-Regulation
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drug effects
Added entries (persons, corporate bodies, meetings, titles ...)
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Sperry, Todd S
(author)
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Thomas, Peter
(author)
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Göteborgs universitetInstitutionen för fysiologi och farmakologi
(creator_code:org_t)
Related titles
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In:General and comparative endocrinology128:3, s. 224-300016-6480
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