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Role of nitric oxid...
Role of nitric oxide in the control of burn perfusion.
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- Lindblom, Lucky, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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- Cassuto, Jean (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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- Yregård, Liselotte (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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- Mattsson, Ulf, 1955 (author)
- Gothenburg University,Göteborgs universitet,Odontologiska institutionen, Avdelningen för endodonti med oral diagnostik,Institute of Odontology, Department of Endodontology/Oral Diagnosis
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- Tarnow, Peter, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för plastikkirurgi,Institute of Surgical Sciences, Department of Plastic Surgery
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- Sinclair, Robert, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Burns : journal of the International Society for Burn Injuries. - 0305-4179. ; 26:1, s. 19-23
- Related links:
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Abstract
Subject headings
Close
- Vascular changes following deep skin burns are characterised by vasoconstriction and progressive ischemia. Nitric oxide (NO) has been shown to be a potent regulator of vascular smooth muscle tone and tissue perfusion. We assessed the importance of NO on post-burn skin perfusion in rats using laser Doppler. The present results show that neither the NO-synthase inhibitor, NG-nitro-L-arginine (L-NNA) (n = 6) nor the NO precursor, L-arginine, significantly influenced skin perfusion in nonburned skin compared to saline-treated animals. In the area of full-thickness skin burn, neither L-arginine (n = 6) nor L-NNA (n = 6) had significant influence on post-burn perfusion compared to saline-treated controls (n = 6). Administration of L-NNA (n = 6) significantly impaired skin perfusion in the area adjacent to the contact burn representing a partial-thickness burn, while the NO precursor, L-arginine (n = 6) had no significant effect on burn perfusion as compared to saline-treated controls (n = 6). In conclusion, impairment of perfusion in a full thickness burn following administration of NO-synthase inhibitor suggests that nitric oxide is involved in the mechanisms responsible for maintaining adequate circulation post-burn. The lack of additional improvement of perfusion in response to L-arginine may suggest that NO synthesis in response to the thermal trauma is already at a peak.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Animals
- Arginine
- pharmacology
- Burns
- physiopathology
- Enzyme Inhibitors
- pharmacology
- Laser-Doppler Flowmetry
- Male
- Nitric Oxide
- physiology
- Nitric Oxide Synthase
- antagonists & inhibitors
- Nitroarginine
- pharmacology
- Rats
- Rats
- Sprague-Dawley
- Skin
- blood supply
Publication and Content Type
- ref (subject category)
- art (subject category)
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