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Microbial modulatio...
Microbial modulation of energy availability in the colon regulates intestinal transit.
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- Wichmann, Anita (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Allahyar, Ava, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Greiner, Thomas U., 1977 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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Plovier, Hubert (author)
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- Östergren Lundén, Gunnel, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Larsson, Thomas, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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Drucker, Daniel J (author)
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Delzenne, Nathalie M (author)
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Cani, Patrice D (author)
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- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Cell host & microbe. - : Elsevier BV. - 1934-6069 .- 1931-3128. ; 14:5, s. 582-90
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Abstract
Subject headings
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- Gut microbiota contribute to host metabolic efficiency by increasing energy availability through thefermentation of dietary fiber and production of short-chain fatty acids (SCFAs) in the colon. SCFAs are proposed to stimulate secretion of the proglucagon (Gcg)-derived incretin hormone GLP-1, whichstimulates insulin secretion (incretin response) andinhibits gastric emptying. We find that germ-free(GF) and antibiotic-treated mice, which have severely reduced SCFA levels, have increased basal GLP-1 levels in the plasma and increased Gcg expression in the colon. Increasing energy supply, either through colonization with polysaccharide-fermenting bacteria or through diet, suppressed colonic Gcg expression in GF mice. Increased GLP-1 levels in GF mice did not improve the incretin response but instead slowed intestinal transit. Thus, microbiota regulate the basal levels of GLP-1, and increasing these levels may be an adaptive response to insufficient energy availability in the colon that slows intestinal transit and allows for greater nutrient absorption.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Wichmann, Anita
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Allahyar, Ava, 1 ...
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Greiner, Thomas ...
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Plovier, Hubert
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Östergren Lundén ...
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Larsson, Thomas, ...
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show more...
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Drucker, Daniel ...
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Delzenne, Nathal ...
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Cani, Patrice D
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Bäckhed, Fredrik ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Cell host & micr ...
- By the university
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University of Gothenburg