Pharmacogenomics and Personalized Medicine in Mood Disorders

Archer, Trevor, 1949 (author): Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology

Karilampi, Ulla (author): Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology

Ricci, S (author)

Rapp-Ricciardi, Max, 1964 (author): Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology

(creator_code:org_t)

Springer, 2013
2013
English.
In: Handbook of Neurotoxicity. - : Springer. - 9781461458357 ; , s. 2181-2205

Abstract Subject headings

Neurotoxic vulnerability that putatively contributes to the etiopathogenesis of schizophrenia spectrum disorders encompasses perinatal adversity, genetic linkage, epigenetic disadvantage, and neurodegenerative propensities that affect both symptom domains, positive, negative, and cognitive and biomarkers of the disorder. Molecular and cellular apoptosis/excitotoxicity that culminates in regional brain loss, reductions reelin expression, trophic disruption, perinatal adversity, glycogen kinase-3 dysregulation, and various instances of oxidative stress all influence the final end point. The existence of prodromal psychotic phases, structural-functional aspects of regional neuroimaging, dopamine signal overexpression, and psychosis propensity provide substance for neurodegenerative influences. The pathophysiology of schizophrenia spectrum disorders encompasses the destruction of normal functioning of the neurotrophins, in particular brain-derived neurotrophic factor (BDNF), dyskinesia of necessary ,ovements, and metabolic-metabolomic and proteomic markers. Neurotoxic accidents combined with genetic susceptibility appear to play a role in interfering with normal neurodevelopment or in tissue-destructive neurodegeneration or both, thereby elevating the eventual risk for disorder tendencies and eventual expression

By the author/editor: Archer, Trevor, ...; Karilampi, Ulla; Ricci, S; Rapp-Ricciardi, ...

About the subject

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