onr:"swepub:oai:gup.ub.gu.se/189871"
Search: onr:"swepub:oai:gup.ub.gu.se/189871" > Fusion oncogenes in...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Stenman, Göran,1953Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center (author)
Fusion oncogenes in salivary gland tumors: molecular and clinical consequences.
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2013-07-03
- Springer Science and Business Media LLC,2013
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/189871
- https://gup.ub.gu.se/publication/189871URI
- https://doi.org/10.1007/s12105-013-0462-zDOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Salivary gland tumors constitute a heterogeneous group of uncommon diseases that pose significant diagnostic and therapeutic challenges. However, the recent discovery of a translocation-generated gene fusion network in salivary gland carcinomas as well in benign salivary gland tumors opens up new avenues for improved diagnosis, prognostication, and development of specific targeted therapies. The gene fusions encode novel fusion oncoproteins or ectopically expressed normal or truncated oncoproteins. The major targets of the translocations are transcriptional coactivators, tyrosine kinase receptors, and transcription factors involved in growth factor signaling and cell cycle regulation. Notably, several of these targets or pathways activated by these targets are druggable. Examples of clinically significant gene fusions in salivary gland cancers are the MYB-NFIB fusion specific for adenoid cystic carcinoma, the CRTC1-MAML2 fusion typical of low/intermediate-grade mucoepidermoid carcinoma, and the recently identified ETV6-NTRK3 fusion in mammary analogue secretory carcinoma. Similarly, gene fusions involving the PLAG1 and HMGA2 oncogenes are specific for benign pleomorphic adenomas. Continued studies of the molecular consequences of these fusion oncoproteins and their down-stream targets will ultimately lead to the identification of novel driver genes in salivary gland neoplasms and will also form the basis for the development of new therapeutic strategies for salivary gland cancers and, perhaps, other neoplasms.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Göteborgs universitetSahlgrenska Cancer Center (creator_code:org_t)
Related titles
- In:Head and Neck: Springer Science and Business Media LLC7:suppl 11043-30741936-055X1936-0568
Internet link
Find in a library
- Head and Neck (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Stenman, Göran, ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- Head and Neck
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
