Optimal ROI Size for Parameter Determination in IVIM Imaging

Montelius, Mikael,1979Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics (author)

Successful delivery of therapy agents to tumor cells depends on tumor tissue perfusion and diffusion. Assessment of these parameters prior to and during treatment would facilitate decision-making regarding e.g. treatment strategy. The intravoxel incoherent motion (IVIM) model (Le Bihan 1988) applied to multi b-value diffusion weighted MRI offers non-invasive quantification of tissue diffusion (D), perfusion-related pseudo diffusion (D*) and perfusion fraction (f). However, the quantification is highly affected by the size of the analyzed region of interest (ROI). In this work, the optimal ROI size for quantification of D, D* and f was determined.

Ljungberg, MariaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics(Swepub:gu)xljmao (author)
Forssell-Aronsson, Eva,1961Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics(Swepub:gu)xforev (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för radiofysik (creator_code:org_t)

In:European Association of Nuclear Medicine (EANM), October 27 - 31, 2012, Milan/ITALY

By the author/editor: Montelius, Mikae ...; Ljungberg, Maria; Forssell-Aronsso ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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