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A genome-wide search for genes predisposing to familial psoriasis by using a stratification approach
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- Samuelsson, Lena, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Enlund, Fredrik, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Torinsson Naluai, Åsa, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children
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- (creator_code:org_t)
- 1999
- 1999
- English.
- In: Hum Genet. - 0340-6717 .- 0340-6717. ; 105:6, s. 523-9
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- We have performed a genome scan, using markers spaced by 10 cM, in the search for psoriasis-susceptibility loci. The family material of 134 affected sibling pairs was ascertained on the basis of a population genetic study in which 65% of the probands had two healthy parents. Genotyping results were analyzed for non-random excessive allele-sharing between sib pairs by using GENEHUNTER ver 1.1. A stratification approach was applied to increase the homogeneity of the material by means of an operational definition of joint complaints among affected individuals. Significant linkage to the human leukocyte antigen region on chromosome 6p in a cohort including 42 families without joint complaints (nonparametric linkage score of 2.83, P=0.002) strongly supported the validity of this operational definition as it replicated results from an earlier linkage report with similar stratification criteria. New candidate regions on chromosomes 3 and 15 were identified. The highest non-parametric linkage values in this study, 2.96 (P=0.0017) and 2.89 (P=0.0020), were reached on chromosome 15 in a subgroup with joint complaints and on chromosome 3 in a subgroup without joint complaints. In addition, confirmation of previously reported loci was established on chromosomes 4q, 6p, and 17q. This study indicates that distinct disease loci might be involved in psoriasis etiology for various phenotypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
Keyword
- Arthritis
- Psoriatic/*genetics
- Chromosomes
- Human
- Pair 15
- Chromosomes
- Human
- Pair 17
- Chromosomes
- Human
- Pair 3
- Chromosomes
- Human
- Pair 4
- Chromosomes
- Human
- Pair 6
- Female
- *Genetic Predisposition to Disease
- *Genome
- Human
- Genotype
- HLA Antigens/genetics
- Humans
- *Linkage (Genetics)
- Male
- Questionnaires
- Statistics
- Nonparametric
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Hum Genet
- By the university
- University of Gothenburg
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