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Usefulness of Plasmodium falciparum-specific rapid diagnostic tests for assessment of parasite clearance and detection of recurrent infections after artemisinin-based combination therapy.
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- Aydin-Schmidt, Berit (author)
- Karolinska Institutet
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- Mubi, Marycelina (author)
- Karolinska Institutet
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- Morris, Ulrika (author)
- Karolinska Institutet
- show more...
- Ngasala, Billy E (author)
- Premji, Zul (author)
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- (creator_code:org_t)
- 2013-10-01
- 2013
- English.
- In: Malaria journal. - : Springer Science and Business Media LLC. - 1475-2875. ; 12:1
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Rapid diagnostic test (RDT) is an important tool for parasite-based malaria diagnosis. High specificity of RDTs to distinguish an active Plasmodium falciparum infection from residual antigens from a previous infection is crucial in endemic areas where residents are repeatedly exposed to malaria. The efficiency of two RDTs based on histidine-rich protein 2 (HRP2) and lactate dehydrogenase (LDH) antigens were studied and compared with two microscopy techniques (Giemsa and acridine orange-stained blood smears) and real-time polymerase chain reaction (PCR) for assessment of initial clearance and detection of recurrent P. falciparum infections after artemisinin-based combination therapy (ACT) in a moderately high endemic area of rural Tanzania.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- University of Gothenburg
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