Search: onr:"swepub:oai:gup.ub.gu.se/193508" >
Genome-wide associa...
Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus
-
Oei, L. (author)
-
Estrada, K. (author)
-
Duncan, E. L. (author)
-
show more...
-
Christiansen, C. (author)
-
Liu, C. T. (author)
-
Langdahl, B. L. (author)
-
Obermayer-Pietsch, B. (author)
-
Riancho, J. A. (author)
-
Prince, R. L. (author)
-
- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for Bone and Arthritis Research,Institute of Medicine, School of Public Health and Community Medicine
-
McCloskey, E. (author)
-
Hsu, Y. H. (author)
-
Evangelou, E. (author)
-
Ntzani, E. (author)
-
Evans, D. M. (author)
-
Alonso, N. (author)
-
Husted, L. B. (author)
-
Valero, C. (author)
-
Hernandez, J. L. (author)
-
Lewis, J. R. (author)
-
Kaptoge, S. K. (author)
-
Zhu, K. (author)
-
Cupples, L. A. (author)
-
Medina-Gomez, C. (author)
-
- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
Kim, G. S. (author)
-
Lee, S. H. (author)
-
Castano-Betancourt, M. C. (author)
-
Oei, E. H. G. (author)
-
Martinez, J. (author)
-
Daroszewska, A. (author)
-
van der Klift, M. (author)
-
- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for Bone and Arthritis Research,Institute of Medicine, School of Public Health and Community Medicine
-
Herrera, L. (author)
-
- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
-
Hofman, A. (author)
-
- Ljunggren, Östen (author)
- Uppsala universitet,Endokrinologi och mineralmetabolism
-
Pols, H. A. P. (author)
-
Stolk, L. (author)
-
van Meurs, J. B. J. (author)
-
Ioannidis, J. P. A. (author)
-
Zillikens, M. C. (author)
-
Lips, P. (author)
-
Karasik, D. (author)
-
Uitterlinden, A. G. (author)
-
Styrkarsdottir, U. (author)
-
Brown, M. A. (author)
-
- Koh, Jung-Min (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Centre for Bone and Arthritis Research,Institute of Medicine
-
Richards, J. B. (author)
-
Reeve, J. (author)
-
- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
Ralston, S. H. (author)
-
Kiel, D. P. (author)
-
Rivadeneira, F. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
-
In: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 59, s. 20-27
- Related links:
-
https://europepmc.or...
-
show more...
-
http://www.ncbi.nlm....
-
http://dx.doi.org/10...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fracture applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55 years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p<5 x 10(-8). In the discovery, a SNP (rs11645938) on chromosome 16q24 was associated with the risk for vertebral fractures at p = 4.6 x 10(-8). However, the association was not significant across 5720 cases and 21,791 controls from 14 studies. Fixed-effects meta-analysis summary estimate was 1.06 (95% Cl: 0.98-1.14; p = 0.17), displaying high degree of heterogeneity (I-2= 57%; Q(het)p = 0.0006). Under Han-Eskin alternative random effects model the summary effect was significant (p = 0.0005). The SNP maps to a region previously found associated with lumbar spine bone mineral density (LS-BMD) in two large meta-analyses from the GEFOS consortium. A false positive association in the GWAS discovery cannot be excluded, yet, the low-powered setting of the discovery and replication settings (appropriate to identify risk effect size >1.25) may still be consistent with an effect size <1.10, more of the type expected in complex traits. Larger effort in studies with standardized phenotype definitions is needed to confirm or reject the involvement of this locus on the risk for vertebral fractures. (C) 2013 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Genome-wide association study
- Vertebral fracture risk
- Genetics of osteoporosis
- GEFOS consortium
- XC2
- BONE-MINERAL DENSITY
- QUALITY-OF-LIFE
- EUROPEAN PROSPECTIVE
- OSTEOPOROSIS
- POSTMENOPAUSAL WOMEN
- GEELONG-OSTEOPOROSIS
- TURNOVER
- MARKERS
- CAMARGO COHORT
- ELDERLY-WOMEN
- Genetics of
- osteoporosis
- FOXC2
- Genome-wide association study
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Bone
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Oei, L.
-
Estrada, K.
-
Duncan, E. L.
-
Christiansen, C.
-
Liu, C. T.
-
Langdahl, B. L.
-
show more...
-
Obermayer-Pietsc ...
-
Riancho, J. A.
-
Prince, R. L.
-
Mellström, Dan, ...
-
McCloskey, E.
-
Hsu, Y. H.
-
Evangelou, E.
-
Ntzani, E.
-
Evans, D. M.
-
Alonso, N.
-
Husted, L. B.
-
Valero, C.
-
Hernandez, J. L.
-
Lewis, J. R.
-
Kaptoge, S. K.
-
Zhu, K.
-
Cupples, L. A.
-
Medina-Gomez, C.
-
Vandenput, Liesb ...
-
Kim, G. S.
-
Lee, S. H.
-
Castano-Betancou ...
-
Oei, E. H. G.
-
Martinez, J.
-
Daroszewska, A.
-
van der Klift, M ...
-
Herrera, L.
-
Karlsson, Magnus
-
Hofman, A.
-
Ljunggren, Östen
-
Pols, H. A. P.
-
Stolk, L.
-
van Meurs, J. B. ...
-
Ioannidis, J. P. ...
-
Zillikens, M. C.
-
Lips, P.
-
Karasik, D.
-
Uitterlinden, A. ...
-
Styrkarsdottir, ...
-
Brown, M. A.
-
Koh, Jung-Min
-
Richards, J. B.
-
Reeve, J.
-
Ohlsson, Claes, ...
-
Ralston, S. H.
-
Kiel, D. P.
-
Rivadeneira, F.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Orthopaedics
- Articles in the publication
-
Bone
- By the university
-
University of Gothenburg
-
Lund University
-
Uppsala University