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Degeneration and re...
Degeneration and regeneration of motor and sensory nerves: a stereological study of crush lesions in rat facial and mental nerves
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- Barghash, Ziad, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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Larsen, J. O. (author)
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Al-Bishri, A. (author)
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- Kahnberg, Karl-Erik, 1941 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027. ; 42:12, s. 1566-1574
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https://doi.org/10.1...
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Abstract
Subject headings
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- The aim of this study was to evaluate the degeneration and regeneration of a sensory nerve and a motor nerve at the histological level after a crush injury. Twenty-five female Wistar rats had their mental nerve and the buccal branch of their facial nerve compressed unilaterally against a glass rod for 30 s. Specimens of the compressed nerves and the corresponding control nerves were dissected at 3, 7, and 19 days after surgery. Nerve cross-sections were stained with osmium tetroxide and toluidine blue and analysed using two-dimensional stereology. We found differences between the two nerves both in the normal anatomy and in the regenerative pattern. The mental nerve had a larger cross-sectional area including all tissue components. The mental nerve had a larger volume fraction of myelinated axons and a correspondingly smaller volume fraction of endoneurium. No differences were observed in the degenerative pattern; however, at day 19 the buccal branch had regenerated to the normal number of axons, whereas the mental nerve had only regained 50% of the normal number of axons. We conclude that the regenerative process is faster and/or more complete in the facial nerve (motor function) than it is in the mental nerve (somatosensory function).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- mental nerve
- facial nerve
- stereology
- rat
- crush lesion
- nerve regeneration
- WALLERIAN DEGENERATION
- PERIPHERAL-NERVE
- MANDIBULAR PROGNATHISM
- TRIGEMINAL NERVE
- AXONS
- OSTEOTOMY
- NEURONS
- RAMUS
- EXPERIENCE
- AXOTOMY
Publication and Content Type
- ref (subject category)
- art (subject category)
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