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Increased frequency...
Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer's disease and frontotemporal dementia.
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- Johansson, Annica, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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Hampel, H (author)
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Faltraco, F (author)
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Buerger, K (author)
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Minthon, L (author)
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- Bogdanovic, N (author)
- Karolinska Institutet
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- Sjögren, Magnus (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
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- Forsell, L (author)
- Karolinska Institutet
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- Lilius, L (author)
- Karolinska Institutet
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Wahlund, L O (author)
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- Rymo, Lars, 1940 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
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Prince, J A (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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(creator_code:org_t)
- Elsevier BV, 2003
- 2003
- English.
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In: Neuroscience letters. - : Elsevier BV. - 0304-3940. ; 340:1, s. 69-73
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Abstract
Subject headings
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- Recent studies show linkage between Alzheimer's disease (AD) and two loci on chromosome 10. The cell division cycle 2 (cdc2) gene is located close to one of the chromosome 10 markers, and is a candidate gene for AD since it is involved in the pathogenesis of AD. We sequenced coding exons and flanking intronic sequences and the promoter region on the cdc2 gene and found three new single nucleotide polymorphisms (SNPs). We analyzed 272 Caucasian AD cases, 160 controls and 70 cases with frontotemporal dementia (FTD) for these SNPs. Homozygosity for one of the SNPs (Ex6+7I/D) was more frequent in both AD and FTD cases than in controls. In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6+7II genotype. Our findings suggest that the Ex6+7I allele is associated with tauopathies, both AD and FTD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Aged
- Aged
- 80 and over
- Alzheimer Disease
- genetics
- Apolipoproteins E
- genetics
- CDC2 Protein Kinase
- genetics
- Cell Division
- genetics
- Dementia
- genetics
- Female
- Gene Frequency
- genetics
- Genetic Predisposition to Disease
- genetics
- Humans
- Male
- Middle Aged
- Polymorphism
- Genetic
- genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johansson, Annic ...
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Hampel, H
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Faltraco, F
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Buerger, K
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Minthon, L
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Bogdanovic, N
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show more...
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Sjögren, Magnus
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Zetterberg, Henr ...
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Forsell, L
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Lilius, L
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Wahlund, L O
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Rymo, Lars, 1940
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Prince, J A
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Blennow, Kaj, 19 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neuroscience let ...
- By the university
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University of Gothenburg
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Karolinska Institutet