Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment

Background Anxiety, apathy and depression are common in subjects with mild cognitive impairment (MCI) and may herald Alzheimer's disease (AD). We investigated whether these symptoms correlated with cerebrospinal fluid (CSF) markers for AD in subjects with MCI. Method Subjects with MCI (n=268) were selected from the 'Development of screening guidelines and criteria for pre-dementia Alzheimer's disease' (DESCRIPA) and Alzheimer's Disease Neuroimaging Initiative (ADNI) studies. We measured amyloid β(1-42) protein (Aβ42) and total tau (t-tau) in CSF. Neuropsychiatric symptoms were measured with the Neuropsychiatric Inventory. Results Depressive symptoms were reported by 55 subjects (21%), anxiety by 35 subjects (13%) and apathy by 49 subjects (18%). The presence of anxiety was associated with abnormal CSF Aβ42 [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.6-3.3] and t-tau (OR 2.6, 95% CI 1.9-3.6) concentrations and with the combination of abnormal concentrations of both Aβ42 and t-tau (OR 3.1, 95% CI 2.0-4.7). The presence of agitation and irritability was associated with abnormal concentrations of Aβ42 (agitation: OR 1.6, 95% CI 1.1-2.3; irritability: OR 2.2, 95% CI 1.5-3.3). Symptoms of depression and apathy were not related to any of the CSF markers. Conclusions In subjects with MCI, symptoms of anxiety, agitation and irritability may reflect underlying AD pathology, whereas symptoms of depression and apathy do not. © 2012 Cambridge University Press.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Alzheimer's disease
anxiety
apathy
biomarkers
cerebrospinal fluid
depression
mild cognitive impairment
neuropsychiatric symptoms
amyloid beta protein
biological marker
tau protein
aged
Alzheimer disease
article
cohort analysis
confidence interval
enzyme linked immunosorbent assay
female
human
irritability
male
neuropsychological test
physiology
psychological aspect
risk
Amyloid beta-Peptides
Biological Markers
Cohort Studies
Confidence Intervals
Enzyme-Linked Immunosorbent Assay
Humans
Irritable Mood
Neuropsychological Tests
Odds Ratio
tau Proteins

Verhey, F. R. J. (author)
Scheltens, P. (author)
Hampel, H. (author)
Soininen, H. (author)
Aalten, P. (author)
Rikkert, M. O. (author)
Verbeek, M. M. (author)
Spiru, L. (author)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Trojanowski, J. Q. (author)
Shaw, L. M. (author)
Visser, P. J. (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

By the author/editor: Ramakers, I. H. ...; Verhey, F. R. J.; Scheltens, P.; Hampel, H.; Soininen, H.; Aalten, P.; show more...; Rikkert, M. O.; Verbeek, M. M.; Spiru, L.; Blennow, Kaj, 19 ...; Trojanowski, J. ...; Shaw, L. M.; Visser, P. J.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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