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  • Burza, Maria Antonella,1980Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine (author)

PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2013-09-19
  • Wiley,2014

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/197119
  • https://gup.ub.gu.se/publication/197119URI
  • https://doi.org/10.1111/liv.12310DOI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background & Aims Environmental and genetic factors contribute to alcoholic cirrhosis onset. In particular, age at exposure to liver stressors has been shown to be important in progression to fibrosis in hepatitis C individuals. However, no definite data on the role of age at onset of at-risk alcohol consumption are available. Moreover, patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M (rs738409) variant has been associated with alcoholic cirrhosis, but only in cross-sectional studies. The aim of this study was to investigate the role of age at onset of at-risk alcohol consumption and PNPLA3 I148M variant on alcoholic cirrhosis incidence. A total of 384 at-risk alcohol drinkers were retrospectively examined. The association among age at onset of at-risk alcohol consumption, PNPLA3 I148M variant and cirrhosis incidence was tested. A higher incidence of alcoholic cirrhosis was observed in individuals with an older (>= 24years) compared with a younger (<24) age at onset of at-risk alcohol consumption (P-value<0.001). Moreover, PNPLA3 148M allele carriers showed an increased incidence of cirrhosis (P-value<0.001). Both age at onset of at-risk alcohol consumption and PNPLA3148M allele were independent risk factors for developing cirrhosis (H.R. (95% C.I.): 2.76 (2.18-3.50), P-value<0.001; 1.53(1.07-2.19), P-value=0.021 respectively). The 148M allele was associated with a two-fold increased risk of cirrhosis in individuals with a younger compared with an older age at onset of at-risk alcohol consumption (H.R. (95% C.I.): 3.03(1.53-6.00) vs. 1.61(1.09-2.38). Age at onset of at-risk alcohol consumption and PNPLA3 I148M genetic variant are independently associated with alcoholic cirrhosis incidence.

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  • Molinaro, A. (author)
  • Attilia, M. L. (author)
  • Rotondo, C. (author)
  • Attilia, F. (author)
  • Ceccanti, M. (author)
  • Ferri, F. (author)
  • Maldarelli, F. (author)
  • Maffongelli, A. (author)
  • De Santis, A. (author)
  • Attili, A. F. (author)
  • Romeo, Stefano,1976Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin,Wallenberg Laboratory,Institute of Medicine(Swepub:gu)xroste (author)
  • Corradini, S. G. (author)
  • Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Related titles

  • In:Liver International: Wiley34:4, s. 514-5201478-32231478-3231

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