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Multivariate evalua...
Multivariate evaluation of doxorubicin surface-enhanced Raman spectra.
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- Eliasson, Charlotte, 1973 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Lorén, Anders, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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Murty, K V (author)
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Josefson, M (author)
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- Käll, Mikael, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU),University of Gothenburg
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- Abrahamsson, Jonas, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,University of Gothenburg
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- Abrahamsson, Katarina, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry,University of Gothenburg
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. - 1386-1425. ; 57:9, s. 1907-15
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Abstract
Subject headings
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- Multivariate evaluation of surface-enhanced Raman spectra of doxorubicin in plasma was performed. In a principal component analysis (PCA) all spectral features were modelled into three principal components. The major variation of the data was shown to be the variation of doxorubicin Raman signal together with the doxorubicin fluorescence, whereas the variation due to plasma was of minor importance. It was also shown that the surface-enhanced Raman scattering (SERS) measurements were independent on such factors as measurement occasion and silver colloids. The presented results show that with some improvements, quantification of doxorubicin directly in plasma could be possible.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Keyword
- Animals
- Antibiotics
- Antineoplastic
- blood
- chemistry
- Cattle
- Doxorubicin
- blood
- chemistry
- Multivariate Analysis
- Plasma
- chemistry
- Principal Component Analysis
- Signal Processing
- Computer-Assisted
- Spectrum Analysis
- Raman
- Multivariate Analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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